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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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Neuroendocrinologie Moleculaire de la Reproduction

Debunking the Myth of the Endogenous Antiangiogenic Vegfaxxxb Transcripts

Trends Endocrinol Metab. 2020 Jun;31(6):398-409.doi: 10.1016/j.tem.2020.01.014. Epub 2020 Feb 12

Debunking the Myth of the Endogenous Antiangiogenic Vegfaxxxb Transcripts
Hugues Dardente , William R English , Manoj K Valluru , Chryso Kanthou , David Simpson


In this opinion article we critically assess evidence for the existence of a family of antiangiogenic vascular endothelial growth factor (Vegfaxxxb) transcripts, arising from the use of a phylogenetically conserved alternative distal splice site within exon 8 of the VEGFA gene. We explain that prior evidence for Vegfaxxxb transcripts in tissues rests heavily upon flawed RT-PCR methodologies, with the extensive use of 5'-tailing in primer design being the main issue. Furthermore, our analysis of large RNA-seq data sets (human and ovine) fails to identify a single Vegfaxxxb transcript. Therefore, we challenge the very existence of Vegfaxxxb transcripts, which further questions the physiological relevance of studies based on the use of 'anti-VEGFAxxxb' antibodies. Our analysis has implications for the proposed therapeutic use of isoform-specific anti-VEGFA strategies for treating cancer and retinopathies.