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INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal Tours university CNRS IFCE

Neuroendocrinologie Moleculaire de la Reproduction

Massimiliano BELTRAMO

All along my career, my research focused on the neural mechanisms controlling major physiological functions (i.e. nociception and reproduction) or implicated in pathological states (i.e. stroke) with the aim of developing new clinical treatment or agronomic applications. I was awarded a master in Biological Science from the University of Turin, Italy, in 1988 and a PhD degree in Neuroscience in 1994 from the Pierre et Marie Curie University (Paris, France). I spent 4 years of post-doctoral training at The Neurosciences Institute of San Diego (CA, USA). In 1998 I moved from Academia to Industry (Schering-Plough) assuming first the position of group leader and then of section head. In 2010 I moved back to Academia and I was appointed research director at the INRA. My main expertise is in the neurobiology, neuropharmacology and drug discovery fields. At present, my research goal is the development and use of kisspeptin analogs suitable for reproduction management in livestock.

Linck to researchgate
Linck to scholar

Publications

In Silico Peptide Ligation: Iterative Residue Docking and Linking as a New Approach to Predict Protein-Peptide Interactions.

Diharce J, Cueto M, Beltramo M, Aucagne V, Bonnet P.

Molecules. 2019 Apr 5;24(7). pii: E1351.

2019

The kisspeptin analog C6 is a possible alternative to PMSG (pregnant mare serum gonadotropin) for triggering synchronized and fertile ovulations in the Alpine goat.

Decourt C, Robert V, Lomet D, Anger K, Georgelin M, Poissenot K, Pellicer-Rubio MT, Aucagne V, Beltramo M.

PLoS One. 2019 Mar 28;14(3):e0214424.

2019

Comments on the paper by Grasselli et al.

Beltramo M.

Theriogenology. 2019 Apr 15;129:178.

2019

Acute and subacute effects of a synthetic kisspeptin analog, C6, on serum concentrations of luteinizing hormone, follicle stimulating hormone, and testosterone in prepubertal bull calves.

Parker PA, Coffman EA, Pohler KG, Daniel JA, Aucagne V, Beltramo M, Whitlock BK.

Theriogenology. 2019 May;130:111-119.

2019

Brain mapping of the gonadotropin-inhibitory hormone-related peptide 2 with a novel antibody suggests a connection with emotional reactivity in the Japanese quail (Coturnix japonica, Temminck & Schlegel, 1849).

Poissenot K, Anger K, Constantin P, Cornilleau F, Lomet D, Tsutsui K, Dardente H, Calandreau L, Beltramo M.

J Comp Neurol. 2019 Aug 1;527(11):1872-1884.

2019

Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation

David Montoir, Mehdi Amoura, Zine El Abidine Ababsa, T. M. Vishwanatha, Expédite Yen-Pon, Vincent Robert, Massimiliano Beltramo, ... Samir Messaoudi

Chem Sci. 2018 Sep 20;9(46):8753-8759.

2018

Cross-Linking Furan-Modified Kisspeptin-10 to the KISS Receptor

W Vannecke, C Ampe, M Van Troys, M Beltramo, A Madder

ACS Chemical Biology 12 (8), 2191-2200

2017

RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents

K Elhabazi, JP Humbert, I Bertin, R Quillet, V Utard, S Schneider, M Beltramo...

Neuropharmacology 118, 188-198

2017

Towards new strategies to manage livestock reproduction using kisspeptin analogs

M Beltramo, C Decourt

Theriogenology

2017

Seasonal breeding in mammals: From basic science to applications and back

H Dardente, D Lomet, V Robert, C Decourt, M Beltramo, ...

Theriogenology 86 (1), 324-332

2016

A synthetic kisspeptin analog that triggers ovulation and advances puberty

C Decourt, V Robert, K Anger, M Galibert, JB Madinier, X Liu, H Dardente, ...,M Beltramo

Scientific reports 6, 26908

2016

No evidence that RFamide related peptide 3 directly modulates LH secretion in the ewe

C Decourt, K Anger, V Robert, D Lomet, J Bartzen-Sprauer, A Caraty, ...,M Beltramo

Endocrinology, en. 2015-1854

2016

Anxiogenic and stressor effects of the hypothalamic neuropeptide RFRP-3 are overcome by the NPFFR antagonist GJ14

JS Kim, PW Brownjohn, BS Dyer, M Beltramo, CS Walker, DL Hay, ...

Endocrinology 156 (11), 4152-4162

2015

Rational Design of Triazololipopeptides Analogs of Kisspeptin Inducing a Long-Lasting Increase of Gonadotropins

M Beltramo, V Robert, M Galibert, JB Madinier, P Marceau, H Dardente, ...

Journal of medicinal chemistry 58 (8), 3459-3470

2015

Le système kisspeptine: au coeur du contrôle de la reproduction

M BELTRAMO, L DUFOURNY

Académie vétérinaire de France, Paris (FRA)

2015

Central control of reproduction: A KISS and beyond

L Dufourny, M Beltramo, P Lonergan, F Mossa, SW Walsh, JJ Ireland, ...

Anim. Front 5 (1), 7-11

2015

Kiss1r receptor agonist compounds and use thereof for inducing ovulation in mammals

M Beltramo, V Aucagne, A Caraty, A Delmas, M Galibert

US Patent App. 14/765,251

2014

Cellular mechanisms and integrative timing of neuroendocrine control of GnRH secretion by kisspeptin

M Beltramo, H Dardente, X Cayla, A Caraty

Molecular and cellular endocrinology 382 (1), 387-399

2014

Acute Injection and Chronic Perfusion of Kisspeptin Elicit Gonadotropins Release but Fail to Trigger Ovulation in the Mare

C Decourt, A Caraty, C Briant, D Guillaume, D Lomet, D Chesneau, ...M Beltramo

Biology of reproduction, biolreprod. 113.114157

2014

LA KISSPEPTINE, UN NOUVEL ACTEUR CLÉ DANS LE CONTRÔLE DE LA REPRODUCTION

M BELTRAMO, A CARATY

Académie vétérinaire de France, Paris (FRA)

2014

ENDOGENOUS LIPIDS THAT ACTIVATE CANNABINOID RECEPTORS

E Di Tomaso, H Cadas, S Gaillet, M Beltramo, F Desarnaud, L Venance

Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and …

2013

Immunohistochemical evidence for the presence of various kisspeptin isoforms in the mammalian brain

I Franceschini, SH Yeo, M Beltramo, E Desroziers, H Okamura, M Beltramo...

Journal of neuroendocrinology 25 (9), 839-851

2013

Gonadotrophin‐Releasing Hormone Release into the Hypophyseal Portal Blood of the Ewe Mirrors Both Pulsatile and Continuous Intravenous Infusion of Kisspeptin: An Insight into …

A Caraty, D Lomet, ME Sébert, D Guillaume, M Beltramo, NP Evans

Journal of neuroendocrinology 25 (6), 537-546

2013

Kisspeptins and the reproductive axis: potential applications to manage reproduction in farm animals

A Caraty, C Decourt, C Briant, M Beltramo

Domestic animal endocrinology 43 (2), 95-102

2012

SAT-507: Kp-16 and Kp-13 Are the Most Abundant Kisspeptin Isoforms Present in Sheep Hypothalamus

A Caraty, J Leprince, D Lomet, B Lefranc, A Bourmaud, ME Sebert, ...

2012

RF9 powerfully stimulates gonadotrophin secretion in the ewe: evidence for a seasonal threshold of sensitivity

A Caraty, M Blomenröhr, GMT Vogel, D Lomet, C Briant, M Beltramo

Journal of neuroendocrinology 24 (5), 725-736

2012

Structure–activity relationships of 2, 4-diphenyl-1< i> H</i>-imidazole analogs as CB2 receptor agonists for the treatment of chronic pain

SW Yang, J Smotryski, J Matasi, G Ho, D Tulshian, WJ Greenlee, R Brusa, M Beltramo...

Bioorganic & medicinal chemistry letters 21 (1), 182-185

2011

Evaluation of Cannabinoid Receptor 2 and Metabotropic Glutamate Receptor 1 Functional Responses Using a Cell Impedance–Based Technology

P Scandroglio, R Brusa, G Lozza, I Mancini, R Petrò, A Reggiani,M Beltramo ...

Journal of biomolecular screening 15 (10), 1238-1247

2010

2 Detecting Constitutive Activity and Protean Agonism at Cannabinoid-2 Receptor

M Beltramo, R Brusa, I Mancini, P Scandroglio

Methods In Enzymology. 484, 31

2010

Constitutive activity of cannabinoid‐2 (CB2) receptors plays an essential role in the protean agonism of (+) AM1241 and L768242

I Mancini, R Brusa, G Quadrato, C Foglia, P Scandroglio, LS Silverman, M Beltramo...

British journal of pharmacology 158 (1), 382-391

2009

Identification of single nucleotide polymorphisms of the human metabotropic glutamate receptor 1 gene and pharmacological characterization of a P993S variant

PM Downey, R Petrò, JS Simon, D Devlin, G Lozza, A Veltri, M Beltramo, ...

Biochemical pharmacology 77 (7), 1246-1253

2009

Cannabinoid type 2 receptor as a target for chronic-pain

M Beltramo

Mini reviews in medicinal chemistry 9 (1), 11-25

2009

[The cannabinoid system and pain: towards new drugs?].

M Beltramo

Journal de la Societe de biologie 203 (1), 99-106

2008

Methods of treating mental diseases, inflammation and pain

M Beltramo, D Piomelli

US Patent App. 11/602,130

2006

CB2 receptor‐mediated antihyperalgesia: possible direct involvement of neural mechanisms

M Beltramo, N Bernardini, R Bertorelli, M Campanella, E Nicolussi, ...

European Journal of Neuroscience 23 (6), 1530-1538

2006

Pigment epithelium‐derived factor is differentially expressed in peripheral neuropathies

A Conti, P Ricchiuto, S Iannaccone, B Sferrazza, A Cattaneo, A Bachi, M Beltramo...

Proteomics 5 (17), 4558-4567

2005

Endogenous and exogenous melanocortin antagonists induce anti-allodynic effects in a model of rat neuropathic pain

R Bertorelli, S Fredduzzi, G Tarozzo, M Campanella, R Grundy, M Beltramo...

Behavioural brain research 157 (1), 55-62

2005

Proteome study of human cerebrospinal fluid following traumatic brain injury indicates fibrin (ogen) degradation products as trauma-associated markers

A Conti, Y Sanchez-Ruiz, A Bachi, L Beretta, E Grandi, M Beltramo, ...

Journal of neurotrauma 21 (7), 854-863

2004

Gene expression profiling of melanocortin system in neuropathic rats supports a role in nociception

M Beltramo, M Campanella, G Tarozzo, S Fredduzzi, L Corradini, ...

Molecular brain research 118 (1), 111-118

2003

Fractalkine protein localization and gene expression in mouse brain

G Tarozzo, S Bortolazzi, C Crochemore, SC Chen, AS Lira, JS Abrams, M Beltramo...

Journal of neuroscience research 73 (1), 81-88

2003

Administering a haloenol lactone as an anandamide amidohydrolase inhibitor; prefered is E-6-(bromomethylene) tetrahydro-3-(1-naphthalenyl)-2H-pyrane-2-one

D Piomelli, M Beltramo

US Patent App. 10/369,794

2003

Expression of fractalkine and its receptor, CX3CR1, in response to ischaemia‐reperfusion brain injury in the rat

G Tarozzo, M Campanella, M Ghiani, A Bulfone, M Beltramo

European Journal of Neuroscience 15 (10), 1663-1668

2002

Flow cytometric analysis of inflammatory cells in ischemic rat brain

M Campanella, C Sciorati, G Tarozzo, M Beltramo

Stroke 33 (2), 586-592

2002

Relationships between CB1 Cannabinoid Receptors and Pituitary Endocrine Cells in< i> Xenopus laevis</i>: An Immunohistochemical Study

R Cesa, A Guastalla, E Cottone, K Mackie, M Beltramo, MF Franzoni

General and comparative endocrinology 125 (1), 17-24

2002

Cannabinoid receptor CB1-like and glutamic acid decarboxylase-like immunoreactivities in the brain of Xenopus laevis

R Cesa, K Mackie, M Beltramo, M Franzoni

Cell and tissue research 306 (3), 391-398

2001

Cannabinoids and neuroprotection

RI Grundy, M Rabuffetti, M Beltramo

Molecular neurobiology 24 (1-3), 29-51

2001

Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology

A Giuffrida, M Beltramo, D Piomelli

Journal of Pharmacology and Experimental Therapeutics 298 (1), 7-14

2001

Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and …

M Rabuffetti, C Sciorati, G Tarozzo, E Clementi, AA Manfredi, M Beltramo

The Journal of Neuroscience 20 (12), 4398-4404

2000

Reversal of dopamine D2 receptor responses by an anandamide transport inhibitor

M Beltramo, FR de Fonseca, M Navarro, A Calignano, MA Gorriti, ...

The Journal of Neuroscience 20 (9), 3401-3407

2000

Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol

M Beltramo, D Piomelli

Neuroreport 11 (6), 1231-1235

2000

Administering haloenol lactone to inhibit anandamide amidohydrolase

D Piomelli, M Beltramo

US Patent 5,925,672

1999

Methods of treating mental diseases, inflammation and pain

M Beltramo, D Piomelli

US Patent 5,925,672

1999

Structural determinants for recognition and translocation by the anandamide transporter

D Piomelli, M Beltramo, S Glasnapp, SY Lin, A Goutopoulos, XQ Xie, M Beltramo..

Proceedings of the National Academy of Sciences 96 (10), 5802-5807

1999

Anandamide transport inhibition by the vanilloid agonist olvanil

M Beltramo, D Piomelli

European journal of pharmacology 364 (1), 75-78

1999

Endogenous cannabinoid signaling

D Piomelli, M Beltramo, A Giuffrida, N Stella

Neurobiology of disease 5 (6), 462-473

1998

Reply: Trick or treat from food endocannabinoids?

M Beltramo, D Piomelli

Nature 396 (6712), 636

1998

Immunolocalization of aromatic L‐amino acid decarboxylase, tyrosine hydroxylase, dopamine, and serotonin in the forebrain of Ambystoma mexicanum

M Beltramo, C Pairault, M Krieger, J Thibault, Y Tillet, P Clairambault

Journal of Comparative Neurology 391 (2), 227-247

1998

Inhibition of intestinal motility by anandamide, an endogenous cannabinoid.

A Calignano, G La Rana, A Makriyannis, SY Lin, M Beltramo, D Piomelli

European journal of pharmacology 340 (2-3), R7-8

1997

Potentiation of anandamide hypotension by the transport inhibitor, AM404

A Calignano, G La Rana, M Beltramo, A Makriyannis, D Piomelli

European journal of pharmacology 337 (1), R1-R2

1997

Functional role of high-affinity anandamide transport, as revealed by selective inhibition

M Beltramo, N Stella, A Calignano, SY Lin, A Makriyannis, D Piomelli

Science 277 (5329), 1094-1097

1997

Long-lasting effect of catecholamine deficiency on differentiating vasopressin and oxytocin neurons in the rat supraoptic nucleus

M Beltramo, A Calas, E Chernigovskaya, J Thibault, M Ugrumov

Neuroscience 79 (2), 555-561

1997

Inhibition of anandamide hydrolysis in rat brain tissue by (E)-6-(bromomethylene) tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one

M Beltramo, E di Tomaso, D Piomelli

FEBS letters 403 (3), 263-267

1997

Endogenous Lipids that Activate Cannabinoid Receptors

E Di Tomaso, H Cadas, S Gaillet, M Beltramo, F Desarnaud, L Venance, ...

Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and …

1997

Brain cannabinoids in chocolate

E Di Tomaso, M Beltramo, D Piomelli

Nature 382 (6593), 677-678

1996

Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP

H Cadas, S Gaillet, M Beltramo, L Venance, D Piomelli

The Journal of neuroscience 16 (12), 3934-3942

1996

Release and inactivation of endogenous cannabinoid substances

D Piomelli, M Beltramo, H Cadas, E Di Tomaso, N Stella

Biological Psychiatry 39 (7), 615-616

1996

A confocal approach to the morphofunctional characterization of the transient tyrosine hydroxylase system in the rat suprachiasmatic nucleus

AA Battaglia, M Beltramo, J Thibault, M Krieger, A Calas

Brain research 696 (1), 7-14

1995

Postnatal development of the suprachiasmatic nucleus in the rat. Morpho-functional characteristics and time course of tyrosine hydroxylase immunopositive fibers

M Beltramo, A Calas, E Chernigovskaya, N Borisova, O Polenova, Y Tillet, ...

Neuroscience 63 (2), 603-610

1994

Immunolocalization of aromatic L‐amino acid decarboxylase in goldfish (Carassius auratus) brain

M Beltramo, M Krieger, Y Tillet, J Thibault, A Calas, V Mazzi, MF Franzoni

Journal of Comparative Neurology 343 (2), 209-227

1994

Aromatic amino acid decarboxylase (AADC) immunohistochemistry in vertebrate brainstem with an antiserum raised against AADC made in< i> E. coli</i>

M Beltramo, M Krieger, A Calas, MF Franzoni, J Thibault

Brain research bulletin 32 (2), 123-132

1993