Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free:

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site:, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Google Analytics

Targeted advertising cookies


The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at or by post at:

24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal Tours university CNRS IFCE

Neuroendocrinologie Moleculaire de la Reproduction

Massimiliano BELTRAMO

All along my career, my research focused on the neural mechanisms controlling major physiological functions (i.e. nociception and reproduction) or implicated in pathological states (i.e. stroke) with the aim of developing new clinical treatment or agronomic applications. I was awarded a master in Biological Science from the University of Turin, Italy, in 1988 and a PhD degree in Neuroscience in 1994 from the Pierre et Marie Curie University (Paris, France). I spent 4 years of post-doctoral training at The Neurosciences Institute of San Diego (CA, USA). In 1998 I moved from Academia to Industry (Schering-Plough) assuming first the position of group leader and then of section head. In 2010 I moved back to Academia and I was appointed research director at the INRA. My main expertise is in the neurobiology, neuropharmacology and drug discovery fields. At present, my research goal is the development and use of kisspeptin analogs suitable for reproduction management in livestock.

Linck to researchgate
Linck to scholar


In Silico Peptide Ligation: Iterative Residue Docking and Linking as a New Approach to Predict Protein-Peptide Interactions.

Diharce J, Cueto M, Beltramo M, Aucagne V, Bonnet P.

Molecules. 2019 Apr 5;24(7). pii: E1351.


The kisspeptin analog C6 is a possible alternative to PMSG (pregnant mare serum gonadotropin) for triggering synchronized and fertile ovulations in the Alpine goat.

Decourt C, Robert V, Lomet D, Anger K, Georgelin M, Poissenot K, Pellicer-Rubio MT, Aucagne V, Beltramo M.

PLoS One. 2019 Mar 28;14(3):e0214424.


Comments on the paper by Grasselli et al.

Beltramo M.

Theriogenology. 2019 Apr 15;129:178.


Acute and subacute effects of a synthetic kisspeptin analog, C6, on serum concentrations of luteinizing hormone, follicle stimulating hormone, and testosterone in prepubertal bull calves.

Parker PA, Coffman EA, Pohler KG, Daniel JA, Aucagne V, Beltramo M, Whitlock BK.

Theriogenology. 2019 May;130:111-119.


Brain mapping of the gonadotropin-inhibitory hormone-related peptide 2 with a novel antibody suggests a connection with emotional reactivity in the Japanese quail (Coturnix japonica, Temminck & Schlegel, 1849).

Poissenot K, Anger K, Constantin P, Cornilleau F, Lomet D, Tsutsui K, Dardente H, Calandreau L, Beltramo M.

J Comp Neurol. 2019 Aug 1;527(11):1872-1884.


Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation

David Montoir, Mehdi Amoura, Zine El Abidine Ababsa, T. M. Vishwanatha, Expédite Yen-Pon, Vincent Robert, Massimiliano Beltramo, ... Samir Messaoudi

Chem Sci. 2018 Sep 20;9(46):8753-8759.


Cross-Linking Furan-Modified Kisspeptin-10 to the KISS Receptor

W Vannecke, C Ampe, M Van Troys, M Beltramo, A Madder

ACS Chemical Biology 12 (8), 2191-2200


RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents

K Elhabazi, JP Humbert, I Bertin, R Quillet, V Utard, S Schneider, M Beltramo...

Neuropharmacology 118, 188-198


Towards new strategies to manage livestock reproduction using kisspeptin analogs

M Beltramo, C Decourt



Seasonal breeding in mammals: From basic science to applications and back

H Dardente, D Lomet, V Robert, C Decourt, M Beltramo, ...

Theriogenology 86 (1), 324-332


A synthetic kisspeptin analog that triggers ovulation and advances puberty

C Decourt, V Robert, K Anger, M Galibert, JB Madinier, X Liu, H Dardente, ...,M Beltramo

Scientific reports 6, 26908


No evidence that RFamide related peptide 3 directly modulates LH secretion in the ewe

C Decourt, K Anger, V Robert, D Lomet, J Bartzen-Sprauer, A Caraty, ...,M Beltramo

Endocrinology, en. 2015-1854


Anxiogenic and stressor effects of the hypothalamic neuropeptide RFRP-3 are overcome by the NPFFR antagonist GJ14

JS Kim, PW Brownjohn, BS Dyer, M Beltramo, CS Walker, DL Hay, ...

Endocrinology 156 (11), 4152-4162


Rational Design of Triazololipopeptides Analogs of Kisspeptin Inducing a Long-Lasting Increase of Gonadotropins

M Beltramo, V Robert, M Galibert, JB Madinier, P Marceau, H Dardente, ...

Journal of medicinal chemistry 58 (8), 3459-3470


Le système kisspeptine: au coeur du contrôle de la reproduction


Académie vétérinaire de France, Paris (FRA)


Central control of reproduction: A KISS and beyond

L Dufourny, M Beltramo, P Lonergan, F Mossa, SW Walsh, JJ Ireland, ...

Anim. Front 5 (1), 7-11


Kiss1r receptor agonist compounds and use thereof for inducing ovulation in mammals

M Beltramo, V Aucagne, A Caraty, A Delmas, M Galibert

US Patent App. 14/765,251


Cellular mechanisms and integrative timing of neuroendocrine control of GnRH secretion by kisspeptin

M Beltramo, H Dardente, X Cayla, A Caraty

Molecular and cellular endocrinology 382 (1), 387-399


Acute Injection and Chronic Perfusion of Kisspeptin Elicit Gonadotropins Release but Fail to Trigger Ovulation in the Mare

C Decourt, A Caraty, C Briant, D Guillaume, D Lomet, D Chesneau, ...M Beltramo

Biology of reproduction, biolreprod. 113.114157




Académie vétérinaire de France, Paris (FRA)



E Di Tomaso, H Cadas, S Gaillet, M Beltramo, F Desarnaud, L Venance

Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and …


Immunohistochemical evidence for the presence of various kisspeptin isoforms in the mammalian brain

I Franceschini, SH Yeo, M Beltramo, E Desroziers, H Okamura, M Beltramo...

Journal of neuroendocrinology 25 (9), 839-851


Gonadotrophin‐Releasing Hormone Release into the Hypophyseal Portal Blood of the Ewe Mirrors Both Pulsatile and Continuous Intravenous Infusion of Kisspeptin: An Insight into …

A Caraty, D Lomet, ME Sébert, D Guillaume, M Beltramo, NP Evans

Journal of neuroendocrinology 25 (6), 537-546


Kisspeptins and the reproductive axis: potential applications to manage reproduction in farm animals

A Caraty, C Decourt, C Briant, M Beltramo

Domestic animal endocrinology 43 (2), 95-102


SAT-507: Kp-16 and Kp-13 Are the Most Abundant Kisspeptin Isoforms Present in Sheep Hypothalamus

A Caraty, J Leprince, D Lomet, B Lefranc, A Bourmaud, ME Sebert, ...


RF9 powerfully stimulates gonadotrophin secretion in the ewe: evidence for a seasonal threshold of sensitivity

A Caraty, M Blomenröhr, GMT Vogel, D Lomet, C Briant, M Beltramo

Journal of neuroendocrinology 24 (5), 725-736


Structure–activity relationships of 2, 4-diphenyl-1< i> H</i>-imidazole analogs as CB2 receptor agonists for the treatment of chronic pain

SW Yang, J Smotryski, J Matasi, G Ho, D Tulshian, WJ Greenlee, R Brusa, M Beltramo...

Bioorganic & medicinal chemistry letters 21 (1), 182-185


Evaluation of Cannabinoid Receptor 2 and Metabotropic Glutamate Receptor 1 Functional Responses Using a Cell Impedance–Based Technology

P Scandroglio, R Brusa, G Lozza, I Mancini, R Petrò, A Reggiani,M Beltramo ...

Journal of biomolecular screening 15 (10), 1238-1247


2 Detecting Constitutive Activity and Protean Agonism at Cannabinoid-2 Receptor

M Beltramo, R Brusa, I Mancini, P Scandroglio

Methods In Enzymology. 484, 31


Constitutive activity of cannabinoid‐2 (CB2) receptors plays an essential role in the protean agonism of (+) AM1241 and L768242

I Mancini, R Brusa, G Quadrato, C Foglia, P Scandroglio, LS Silverman, M Beltramo...

British journal of pharmacology 158 (1), 382-391


Identification of single nucleotide polymorphisms of the human metabotropic glutamate receptor 1 gene and pharmacological characterization of a P993S variant

PM Downey, R Petrò, JS Simon, D Devlin, G Lozza, A Veltri, M Beltramo, ...

Biochemical pharmacology 77 (7), 1246-1253


Cannabinoid type 2 receptor as a target for chronic-pain

M Beltramo

Mini reviews in medicinal chemistry 9 (1), 11-25


[The cannabinoid system and pain: towards new drugs?].

M Beltramo

Journal de la Societe de biologie 203 (1), 99-106


Methods of treating mental diseases, inflammation and pain

M Beltramo, D Piomelli

US Patent App. 11/602,130


CB2 receptor‐mediated antihyperalgesia: possible direct involvement of neural mechanisms

M Beltramo, N Bernardini, R Bertorelli, M Campanella, E Nicolussi, ...

European Journal of Neuroscience 23 (6), 1530-1538


Pigment epithelium‐derived factor is differentially expressed in peripheral neuropathies

A Conti, P Ricchiuto, S Iannaccone, B Sferrazza, A Cattaneo, A Bachi, M Beltramo...

Proteomics 5 (17), 4558-4567


Endogenous and exogenous melanocortin antagonists induce anti-allodynic effects in a model of rat neuropathic pain

R Bertorelli, S Fredduzzi, G Tarozzo, M Campanella, R Grundy, M Beltramo...

Behavioural brain research 157 (1), 55-62


Proteome study of human cerebrospinal fluid following traumatic brain injury indicates fibrin (ogen) degradation products as trauma-associated markers

A Conti, Y Sanchez-Ruiz, A Bachi, L Beretta, E Grandi, M Beltramo, ...

Journal of neurotrauma 21 (7), 854-863


Gene expression profiling of melanocortin system in neuropathic rats supports a role in nociception

M Beltramo, M Campanella, G Tarozzo, S Fredduzzi, L Corradini, ...

Molecular brain research 118 (1), 111-118


Fractalkine protein localization and gene expression in mouse brain

G Tarozzo, S Bortolazzi, C Crochemore, SC Chen, AS Lira, JS Abrams, M Beltramo...

Journal of neuroscience research 73 (1), 81-88


Administering a haloenol lactone as an anandamide amidohydrolase inhibitor; prefered is E-6-(bromomethylene) tetrahydro-3-(1-naphthalenyl)-2H-pyrane-2-one

D Piomelli, M Beltramo

US Patent App. 10/369,794


Expression of fractalkine and its receptor, CX3CR1, in response to ischaemia‐reperfusion brain injury in the rat

G Tarozzo, M Campanella, M Ghiani, A Bulfone, M Beltramo

European Journal of Neuroscience 15 (10), 1663-1668


Flow cytometric analysis of inflammatory cells in ischemic rat brain

M Campanella, C Sciorati, G Tarozzo, M Beltramo

Stroke 33 (2), 586-592


Relationships between CB1 Cannabinoid Receptors and Pituitary Endocrine Cells in< i> Xenopus laevis</i>: An Immunohistochemical Study

R Cesa, A Guastalla, E Cottone, K Mackie, M Beltramo, MF Franzoni

General and comparative endocrinology 125 (1), 17-24


Cannabinoid receptor CB1-like and glutamic acid decarboxylase-like immunoreactivities in the brain of Xenopus laevis

R Cesa, K Mackie, M Beltramo, M Franzoni

Cell and tissue research 306 (3), 391-398


Cannabinoids and neuroprotection

RI Grundy, M Rabuffetti, M Beltramo

Molecular neurobiology 24 (1-3), 29-51


Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology

A Giuffrida, M Beltramo, D Piomelli

Journal of Pharmacology and Experimental Therapeutics 298 (1), 7-14


Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and …

M Rabuffetti, C Sciorati, G Tarozzo, E Clementi, AA Manfredi, M Beltramo

The Journal of Neuroscience 20 (12), 4398-4404


Reversal of dopamine D2 receptor responses by an anandamide transport inhibitor

M Beltramo, FR de Fonseca, M Navarro, A Calignano, MA Gorriti, ...

The Journal of Neuroscience 20 (9), 3401-3407


Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol

M Beltramo, D Piomelli

Neuroreport 11 (6), 1231-1235


Administering haloenol lactone to inhibit anandamide amidohydrolase

D Piomelli, M Beltramo

US Patent 5,925,672


Methods of treating mental diseases, inflammation and pain

M Beltramo, D Piomelli

US Patent 5,925,672


Structural determinants for recognition and translocation by the anandamide transporter

D Piomelli, M Beltramo, S Glasnapp, SY Lin, A Goutopoulos, XQ Xie, M Beltramo..

Proceedings of the National Academy of Sciences 96 (10), 5802-5807


Anandamide transport inhibition by the vanilloid agonist olvanil

M Beltramo, D Piomelli

European journal of pharmacology 364 (1), 75-78


Endogenous cannabinoid signaling

D Piomelli, M Beltramo, A Giuffrida, N Stella

Neurobiology of disease 5 (6), 462-473


Reply: Trick or treat from food endocannabinoids?

M Beltramo, D Piomelli

Nature 396 (6712), 636


Immunolocalization of aromatic L‐amino acid decarboxylase, tyrosine hydroxylase, dopamine, and serotonin in the forebrain of Ambystoma mexicanum

M Beltramo, C Pairault, M Krieger, J Thibault, Y Tillet, P Clairambault

Journal of Comparative Neurology 391 (2), 227-247


Inhibition of intestinal motility by anandamide, an endogenous cannabinoid.

A Calignano, G La Rana, A Makriyannis, SY Lin, M Beltramo, D Piomelli

European journal of pharmacology 340 (2-3), R7-8


Potentiation of anandamide hypotension by the transport inhibitor, AM404

A Calignano, G La Rana, M Beltramo, A Makriyannis, D Piomelli

European journal of pharmacology 337 (1), R1-R2


Functional role of high-affinity anandamide transport, as revealed by selective inhibition

M Beltramo, N Stella, A Calignano, SY Lin, A Makriyannis, D Piomelli

Science 277 (5329), 1094-1097


Long-lasting effect of catecholamine deficiency on differentiating vasopressin and oxytocin neurons in the rat supraoptic nucleus

M Beltramo, A Calas, E Chernigovskaya, J Thibault, M Ugrumov

Neuroscience 79 (2), 555-561


Inhibition of anandamide hydrolysis in rat brain tissue by (E)-6-(bromomethylene) tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one

M Beltramo, E di Tomaso, D Piomelli

FEBS letters 403 (3), 263-267


Endogenous Lipids that Activate Cannabinoid Receptors

E Di Tomaso, H Cadas, S Gaillet, M Beltramo, F Desarnaud, L Venance, ...

Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and …


Brain cannabinoids in chocolate

E Di Tomaso, M Beltramo, D Piomelli

Nature 382 (6593), 677-678


Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP

H Cadas, S Gaillet, M Beltramo, L Venance, D Piomelli

The Journal of neuroscience 16 (12), 3934-3942


Release and inactivation of endogenous cannabinoid substances

D Piomelli, M Beltramo, H Cadas, E Di Tomaso, N Stella

Biological Psychiatry 39 (7), 615-616


A confocal approach to the morphofunctional characterization of the transient tyrosine hydroxylase system in the rat suprachiasmatic nucleus

AA Battaglia, M Beltramo, J Thibault, M Krieger, A Calas

Brain research 696 (1), 7-14


Postnatal development of the suprachiasmatic nucleus in the rat. Morpho-functional characteristics and time course of tyrosine hydroxylase immunopositive fibers

M Beltramo, A Calas, E Chernigovskaya, N Borisova, O Polenova, Y Tillet, ...

Neuroscience 63 (2), 603-610


Immunolocalization of aromatic L‐amino acid decarboxylase in goldfish (Carassius auratus) brain

M Beltramo, M Krieger, Y Tillet, J Thibault, A Calas, V Mazzi, MF Franzoni

Journal of Comparative Neurology 343 (2), 209-227


Aromatic amino acid decarboxylase (AADC) immunohistochemistry in vertebrate brainstem with an antiserum raised against AADC made in< i> E. coli</i>

M Beltramo, M Krieger, A Calas, MF Franzoni, J Thibault

Brain research bulletin 32 (2), 123-132