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INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal Tours university CNRS IFCE

Neuroendocrinologie Moleculaire de la Reproduction

Laurence DUFOURNY

CRCN-HDR

Laurence Dufourny
© INRA

Ph.D Thesis defended in 1999 (Université de Lille 1 (France)/INSERM U422)

Post-docs: University of Bristol (UK, 2000-2002), University of Wyoming (USA, 2002-2003), and INRA Tours (France, 2003-2004).

Research scientist employed by CNRS from 2004, job located at INRA Tours.

Research interests :

Having studied from the start of my career on the central control of ovulation and neuronal networks driving sexual behavior, I am deeply interested in the influence of endogenous hormones (steroids, melatonin and metabolic hormones) and neuromodulators on neuronal populations driving ovulation and more specifically, kisspeptin and GnRH neurons. My goal is to unravel the different regulatory pathways and the different components involved in the stimulation/inhibition of kisspeptin release and hence GnRH secretion.  I am working on the ovine species as it is a well-known model for a specific aspect of reproduction, seasonal reproduction, consisting of 6 months with ovarian activity followed by 6 months of sexual rest. I am also using rodents namely for experiments involving specific metabolic regimen and/or consecutive neurosurgical approaches.

Linck to scholar
Linck to researchgate

Publications :

Diabetes Type 2 and Kisspeptin: Central and Peripheral Sex-Specific Actions.

Dudek M, Ziarniak K, Cateau ML, Dufourny L, Sliwowska JH.

Trends Endocrinol Metab. 2019 Nov;30(11):833-843.

2019

Neuroanatomical connections between kisspeptin neurones and somatostatin neurones in the female and male rat hypothalamus: A possible involvement of SSTR 1 in kisspeptin release

L Dufourny, O Delmas, AP Teixeira‐Gomes, C Decourt, JH Sliwowska

Journal of neuroendocrinology 30 (5), e12593

2018

Crosstalks between kisspeptin neurons and somatostatin neurons are not photoperiod dependent in the ewe hypothalamus

L Dufourny, D Lomet

General and comparative endocrinology 254, 68-74

2017

The" ram effect": a model to understand the role of kisspeptin as a relay between socio-sexual interactions and the gonadotropic axis

C Fabre-Nys, L Dufourny, R Scaramuzzi

47. European Brain and Behaviour Society Meeting, np

2017

The two populations of kisspeptin neurons are Involved in the ram-induced LH pulsatile secretion and LH surge in anestrous ewes

C Fabre-Nys, J Cognié, L Dufourny, M Ghenim, S Martinet, O Lasserre,  L Dufourny...

Endocrinology 158 (11), 3914-3928

2017

No evidence that RFamide-related peptide 3 directly modulates LH secretion in the ewe

C Decourt, K Anger, V Robert, D Lomet, J Bartzen-Sprauer, A Caraty,  L Dufourny...

Endocrinology 157 (4), 1566-1575

2016

The Content of Thyroid Hormone Receptor α in Ewe Kisspeptin Neurones is not Season‐Dependent

L Dufourny, D Gennetay, S Martinet, D Lomet, A Caraty

Journal of neuroendocrinology 28 (2)

2016

PCB153 (2, 2′, 4, 4′, 5, 5′-hexachlorobiphenyl) differentially affects the VEGF/VEGFR system depending on photoperiod in the ovine choroid plexus

A Szczepkowska, C Lagaraine, V Robert, J Młynarczuk, L Dufourny, ...

Ecotoxicology and environmental safety 124, 303-308

2016

Design, synthesis and biological evaluation of fluorescent ligands for MT 1 and/or MT 2 melatonin receptors

G Viault, S Poupart, S Mourlevat, C Lagaraine, S Devavry, F Lefoulon,  L Dufourny ...

RSC Advances 6 (67), 62508-62521

2016

Photoperiod affects the cerebrospinal fluid proteome: a comparison between short day–and long day–treated ewes

AP Teixeira-Gomes, G Harichaux, D Gennetay, J Skipor, JC Thiery,  L Dufourny...

Domestic animal endocrinology 53, 1-8

2015

Le système kisspeptine: au coeur du contrôle de la reproduction

M BELTRAMO, L DUFOURNY

Académie vétérinaire de France, Paris (FRA)

2015

Central control of reproduction: A KISS and beyond

L Dufourny, M Beltramo

Animal Frontiers 5 (1), 7-11

2015

Acute injection and chronic perfusion of kisspeptin elicit gonadotropins release but fail to trigger ovulation in the mare

C Decourt, A Caraty, C Briant, D Guillaume, D Lomet, D Chesneau,  L Dufourny...

Biology of reproduction 90 (2)

2014

Original design of fluorescent ligands by fusing BODIPY and melatonin neurohormone

J Thireau, J Marteaux, P Delagrange, F Lefoulon, L Dufourny, ...

ACS medicinal chemistry letters 5 (2), 158-161

2013

Effect of a two-week treatment with a low dose of 2, 2′ 4, 4′, 5, 5′-hexachlorobiphenyl (PCB153) on tight junction protein expression in ovine choroid plexus during long and …

A Szczepkowska, C Lagaraine, V Robert, L Dufourny, JC Thiéry, J Skipor

Neurotoxicology and teratology 37, 63-67

2013

Photoperiodic variations of the polysialylated form of neural cell adhesion molecule within the hypothalamus and related reproductive output in the ewe

S Chalivoix, D Guillaume, J Cognié, JC Thiéry, B Malpaux, L Dufourny

Cell and tissue research 352 (2), 387-399

2013

Erratum to: GPR50 is the mammalian ortholog of Mel1c: Evidence of rapid evolution in mammals

L Dufourny, A Levasseur, M Migaud, I Callebaut, P Pontarotti, B Malpaux, ...

BMC evolutionary biology 12 (1), 28

2012

Effect of a two-week treatment with low dose of ortho-substituted polychlorinated biphenyls (PCB104 and PCB153) on VEGF-receptor system expression in the choroid plexus in …

A Szczepkowska, J Młynarczuk, A Grochowalski, L Dufourny, JC Thiéry, ...

Polish journal of veterinary sciences 15 (4), 621-628

2012

Pattern of expression of vascular endothelial growth factor and its receptors in the ovine choroid plexus during long and short photoperiods

A Szczepkowska, B Wąsowska, PD Gilun, C Lagaraine, V Robert,  L Dufourny ...

Cell and tissue research 350 (1), 157-166

2012

Photoperiod modulates access of 2, 2′, 4, 4′, 5, 5′-hexachlorobiphenyl (PCB153) to the brain and its effect on gonadotropin and thyroid hormones in adult ewes

J Skipor, JŁ MŁynarczuk, A Szczepkowska, C Lagaraine, A Grochowalski,  L Dufourny...

Ecotoxicology and environmental safety 78, 336-343

2012

Breeders give the rhythm

L Dufourny

BIOFUTUR, 42-42

2011

Tight junction proteins vary in the choroid plexus of ewes according to photoperiod

C Lagaraine, J Skipor, A Szczepkowska, L Dufourny, JC Thiery

Brain research 1393, 44-51

2011

Zoom: Les éleveurs donnent le rythme

L Dufourny

Biofutur, 42-42

2011

Relationship between polysialylated neural cell adhesion molecule and β-endorphin-or gonadotropin releasing hormone-containing neurons during activation of the gonadotrope axis …

S Chalivoix, B Malpaux, L Dufourny

Neuroscience 169 (3), 1326-1336

2010

Effects of photoperiod on kisspeptin neuronal populations of the ewe diencephalon in connection with reproductive function

S Chalivoix, A Bagnolini, A Caraty, J Cognié, B Malpaux, L Dufourny

Journal of neuroendocrinology 22 (2), 110-118

2010

GPR50 is the mammalian ortholog of Mel1c: evidence of rapid evolution in mammals

L Dufourny, A Levasseur, M Migaud, I Callebaut, P Pontarotti, B Malpaux, ...

BMC evolutionary biology 8 (1), 105

2008

Immunoreactive GnRH type I receptors in the mouse and sheep brain

AJ Albertson, A Navratil, M Mignot, L Dufourny, B Cherrington, ...

Journal of chemical neuroanatomy 35 (4), 326-333

2008

Development of an in vivo adeno-associated virus-mediated siRNA approach to knockdown tyrosine hydroxylase in the lateral retrochiasmatic area of the ovine brain

L Dufourny, M Migaud, JC Thiery, B Malpaux

Journal of neuroscience methods 170 (1), 56-66

2008

No effect of nutrient restriction from gestational days 28 to 78 on immunocytochemically detectable growth hormone-releasing hormone (GHRH) neurons and GHRH receptor …

L Lutz, N Schoefield, C Crowe, L Dufourny, DC Skinner

Journal of chemical neuroanatomy 33 (1), 34-41

2007

Effect of nutrient restriction on the somatotropes and substance P-immunoreactive cells in the pituitary of the female ovine fetus

L Lutz, L Dufourny, DC Skinner

Growth hormone & IGF research 16 (2), 108-118

2006

Distribution of galanin receptor 1-immunoreactive neurons in the ovine hypothalamus: colocalization with GnRH

L Dufourny, DC Skinner

Brain research 1054 (1), 73-81

2005

ENETS Newsletter

MT Zomerhuis, SM Hussain, RA Feelders, AJ van der Lely, WW de Herder,  L Dufourny...

Neuroendocrinology 82 (1), 59-62

2005

Progesterone-receptive dopaminergic and neuropeptide Y neurons project from the arcuate nucleus to gonadotropin-releasing hormone-rich regions of the ovine preoptic area

L Dufourny, A Caraty, IJ Clarke, JE Robinson, DC Skinner

Neuroendocrinology 82 (1), 21-31

2005

Progesterone-receptive β-endorphin and dynorphin B neurons in the arcuate nucleus project to regions of high gonadotropin-releasing hormone neuron density in the ovine preoptic …

L Dufourny, A Caraty, IJ Clarke, JE Robinson, DC Skinner

Neuroendocrinology 81 (3), 139-149

2005

Oestrogen Receptor β‐Immunoreactive Neurones in the Ovine Hypothalamus: Distribution and Colocalisation with Gonadotropin‐Releasing Hormone

DC Skinner, L Dufourny

Journal of neuroendocrinology 17 (1), 29-39

2005

Galanin receptor (GAL-R1, GAL-R2) immunoreactivity in the ovine hypothalamus: Colocalization with GnRH

L Dufourny, D Skinner

Biology of Reproduction, 122-122

2004

Immunoreactive galanin expression in ovine gonadotropin‐releasing hormone neurones: no effects of gender or reproductive status

L Dufourny, N Schofield, DC Skinner

Journal of neuroendocrinology 15 (11), 1062-1069

2003

Somatostatin-14 neurons in the ovine hypothalamus: colocalization with estrogen receptor α and somatostatin-28 (1–12) immunoreactivity, and activation in response to estradiol

N Scanlan, L Dufourny, DC Skinner

Biology of reproduction 69 (4), 1318-1324

2003

Immunoreactive GnRH neurons in the main olfactory bulb of the ewe.

DC Skinner, HA Harness, L Dufourny

BIOLOGY OF REPRODUCTION 68, 376-376

2003

Galanin and GnRH co-localization in the ovine brain.

L Dufourny, DC Skinner

BIOLOGY OF REPRODUCTION 68, 377-377

2003

Colocalization of progesterone receptors and thyroid hormone receptors alpha in the ovine diencephalon: no effect of estradiol

L Dufourny, DC Skinner

Neuroendocrinology 77 (1), 51-58

2003

Progesterone receptor, estrogen receptor α, and the type II glucocorticoid receptor are coexpressed in the same neurons of the ovine preoptic area and arcuate nucleus: a triple …

L Dufourny, DC Skinner

Biology of reproduction 67 (5), 1605-1612

2002

Influence of estradiol on NADPH diaphorase/neuronal nitric oxide synthase activity and colocalization with progesterone or type II glucocorticoid receptors in ovine hypothalamus

L Dufourny, DC Skinner

Biology of reproduction 67 (3), 829-836

2002

Type II glucocorticoid receptors in the ovine hypothalamus: distribution, influence of estrogen and absence of co-localization with GnRH

L Dufourny, DC Skinner

Brain research 946 (1), 79-86

2002

Perinatal malnutrition programs sympathoadrenal and hypothalamic‐pituitary‐adrenal axis responsiveness to restraint stress in adult male rats

J Lesage, L Dufourny, C Laborie, F Bernet, B Blondeau, I Avril, B Breant, ...

Journal of neuroendocrinology 14 (2), 135-143

2002

Perinatal maternal food restriction induces alterations in hypothalamo-pituitary-adrenal axis activity and in plasma corticosterone-binding globulin capacity of weaning rat pups

M Léonhardt, J Lesage, L Dufourny, A Dickès-Coopman, V Montel, ...

Neuroendocrinology 75 (1), 45-54

2002

Projections from ventrolateral hypothalamic neurons containing progesterone receptors and somatostatin to the midbrain central gray in the female guinea pig

L Dufourny, M Warembourg

Experimental brain research 136 (1), 50-59

2001

Progesterone receptor-containing neurons show estrogen receptor alpha immunoreactivity in the ovine preoptic area and hypothalamus.

L Dufourny, DC Skinner

Biology of Reproduction 64, 115-115

2001

Differential effects of colchicine on the induction of nitric oxide synthase in neurons containing progesterone receptors of the guinea pig hypothalamus

L Dufourny, D Leroy, M Warembourg

Brain research bulletin 52 (5), 435-443

2000

Quantitative studies of progesterone receptor and nitric oxide synthase colocalization with somatostatin, or neurotensin, or substance P in neurons of the guinea pig …

L Dufourny, M Warembourg, A Jolivet

Journal of chemical neuroanatomy 17 (1), 33-43

1999

Estrogen modulation of neuropeptides: somatostatin, neurotensin and substance P, in the ventrolateral and arcuate nuclei of the female guinea pig

L Dufourny, M Warembourg

Neuroscience research 33 (3), 223-228

1999

Multiple Peptides Infrequently Coexist in Progesterone Receptor‐Containing Neurons in the Ventrolateral Hypothalamic Nucleus of the Guinea‐Pig: An Immunocytochemical Triple …

L Dufourny, M Warembourg, A Jolivet

Journal of neuroendocrinology 10 (3), 165-173

1998

Sex differences in estradiol-induced progestin receptor immunoreactivity in the guinea pig preoptic area and hypothalamus

L Dufourny, M Warembourg, A Jolivet

Neuroscience letters 223 (2), 109-112

1997

Colocalization of progesterone receptor and somatostatin immunoreactivities in the hypothalamus of the male and female guinea pig

L Dufourny, M Warembourg

Neuroendocrinology 64 (3), 215-224

1996

Le recepteur de la progesterone dans le noyau ventrolateral du cobaye: colocalisation avec la neurotensine et la somatostatine

L Dufourny, M Warembourg

Annales d'Endocrinologie 56 (4), 437-437