Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free:

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site:, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Google Analytics

Targeted advertising cookies


The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at or by post at:

24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal Tours university CNRS IFCE

Neuroendocrinologie Moleculaire de la Reproduction



Text in progress!


Sexually dimorphic gene expression and neurite sensitivity to estradiol in fetal arcuate Kiss1 cells.

Alfaia C, Robert V, Poissenot K, Levern Y, Guillaume D, Yeo S, Colledge W, Franceschini I.

J Endocrinol. 2019 Oct 1. pii: JOE-18-0142.R2.


Effects of combined exposure of adult male mice to di-(2-ethylexyl)phthalate and nonylphenol on behavioral and neuroendocrine responses.

Capela D, Poissenot K, Dombret C, Keller M, Franceschini I, Mhaouty-Kodja S.

Chemosphere. 2019 Apr;221:573-582.


Batf3-Dependent Intestinal Dendritic Cells Play a Critical Role in the Control of Cryptosporidium parvum Infection.

Potiron L, Lacroix-Lamandé S, Marquis M, Levern Y, Fort G, Franceschini I, Laurent F.

J Infect Dis. 2019 Feb 23;219(6):925-935.


Adult male mice exposure to nonylphenol alters courtship vocalizations and mating.

Capela D, Dombret C, Poissenot K, Poignant M, Malbert-Colas A, Franceschini I, Keller M, Mhaouty-Kodja S.

Sci Rep. 2018 Feb 14;8(1):2988.


Neural Mechanisms Underlying the Disruption of Male Courtship Behavior by Adult Exposure to Di(2-ethylhexyl) Phthalate in Mice.

Dombret C, Capela D, Poissenot K, Parmentier C, Bergsten E, Pionneau C, Chardonnet S, Hardin-Pouzet H, Grange-Messent V, Keller M, Franceschini I, Mhaouty-Kodja S.

Environ Health Perspect. 2017 Sep 1;125(9):097001.


GnRH Episodic Secretion Is Altered by Pharmacological Blockade of Gap Junctions: Possible Involvement of Glial Cells.

Pinet-Charvet C, Geller S, Desroziers E, Ottogalli M, Lomet D, Georgelin C, Tillet Y, Franceschini I, Vaudin P, Duittoz A.

Endocrinology. 2016 Jan;157(1):304-22.


Delayed pubertal onset and prepubertal Kiss1 expression in female mice lacking central oestrogen receptor beta.

Naulé L, Robert V, Parmentier C, Martini M, Keller M, Cohen-Solal M, Hardin-Pouzet H, Grange-Messent V, Franceschini I, Mhaouty-Kodja S.

Hum Mol Genet. 2015 Dec 20;24(25):7326-38.


Neuroendocrine and behavioral effects of maternal exposure to oral bisphenol A in female mice.

Naulé L, Picot M, Martini M, Parmentier C, Hardin-Pouzet H, Keller M, Franceschini I, Mhaouty-Kodja S.

J Endocrinol. 2014 Feb 10;220(3):375-88.


Vulnerability of the neural circuitry underlying sexual behavior to chronic adult exposure to oral bisphenol a in male mice.

Picot M, Naulé L, Marie-Luce C, Martini M, Raskin K, Grange-Messent V, Franceschini I, Keller M, Mhaouty-Kodja S.

Endocrinology. 2014 Feb;155(2):502-12.


Immunohistochemical evidence for the presence of various kisspeptin isoforms in the mammalian brain.

Franceschini I, Yeo SH, Beltramo M, Desroziers E, Okamura H, Herbison AE, Caraty A.

J Neuroendocrinol. 2013 Sep;25(9):839-51.


Comparative analysis of kisspeptin-immunoreactivity reveals genuine differences in the hypothalamic Kiss1 systems between rats and mice.

Overgaard A, Tena-Sempere M, Franceschini I, Desroziers E, Simonneaux V, Mikkelsen JD

Peptides. 2013 Jul;45:85-90.


Development and Aging of the Kisspeptin-GPR54 System in the Mammalian Brain: What are the Impacts on Female Reproductive Function?

Franceschini I, Desroziers E.

Front Endocrinol (Lausanne). 2013 Mar 28;4:22. doi: 10.3389/fendo.2013.00022. eCollection 2013.


Embryonic development of kisspeptin neurones in rat.

Desroziers E, Droguerre M, Bentsen AH, Robert V, Mikkelsen JD, Caraty A, Tillet Y, Duittoz A, Franceschini I.

J Neuroendocrinol. 2012 Oct;24(10):1284-95.


Kisspeptin-immunoreactivity changes in a sex- and hypothalamic-region-specific manner across rat postnatal development.

Desroziers E, Mikkelsen JD, Duittoz A, Franceschini I.

J Neuroendocrinol. 2012 Aug;24(8):1154-65.


Seasonal changes in cell proliferation in the adult sheep brain and pars tuberalis.

Migaud M, Batailler M, Pillon D, Franceschini I, Malpaux B.

J Biol Rhythms. 2011 Dec;26(6):486-96.


Emerging new sites for adult neurogenesis in the mammalian brain: a comparative study between the hypothalamus and the classical neurogenic zones.

Migaud M, Batailler M, Segura S, Duittoz A, Franceschini I, Pillon D.

Eur J Neurosci. 2010 Dec;32(12):2042-52.


The intimate relationship of gonadotropin-releasing hormone neurons with the polysialylated neural cell adhesion molecule revisited across development and adult plasticity.

Franceschini I, Desroziers E, Caraty A, Duittoz A.

Eur J Neurosci. 2010 Dec;32(12):2031-41.


Expression of fos and in vivo median eminence release of LHRH identifies an active role for preoptic area kisspeptin neurons in synchronized surges of LH and LHRH in the ewe.

Hoffman GE, Le WW, Franceschini I, Caraty A, Advis JP.

Endocrinology. 2011 Jan;152(1):214-22.


Evidence for cell proliferation in the sheep brain and its down-regulation by parturition and interactions with the young.

Brus M, Meurisse M, Franceschini I, Keller M, Lévy F.

Horm Behav. 2010 Nov;58(5):737-46.


Mapping of kisspeptin fibres in the brain of the pro-oestrous rat.

Desroziers E, Mikkelsen J, Simonneaux V, Keller M, Tillet Y, Caraty A, Franceschini I.

J Neuroendocrinol. 2010 Oct;22(10):1101-12.


Kisspeptin and the preovulatory gonadotrophin-releasing hormone/luteinising hormone surge in the ewe: basic aspects and potential applications in the control of ovulation.

Caraty A, Franceschini I, Hoffman GE.

J Neuroendocrinol. 2010 Jul;22(7):710-5.


[Hypothalamic neuropeptides and control of GnRH neurones. Neuroanatomical study in the ewe].

Tillet Y, Picard S, Franceschini I.

J Soc Biol. 2009;203(1):19-28.


Kisspeptin immunoreactive neurons in the equine hypothalamus Interactions with GnRH neuronal system.

Decourt C, Tillet Y, Caraty A, Franceschini I, Briant C.

J Chem Neuroanat. 2008 Dec;36(3-4):131-7.


Basic aspects of the control of GnRH and LH secretions by kisspeptin: potential applications for better control of fertility in females.

Caraty A, Franceschini I.

Reprod Domest Anim. 2008 Jul;43 Suppl 2:172-8.


In vitro migration assays of neural stem cells.

Durbec P, Franceschini I, Lazarini F, Dubois-Dalcq M.

Methods Mol Biol. 2008;438:213-25.


Neural cell adhesion molecule polysialylation enhances the sensitivity of embryonic stem cell-derived neural precursors to migration guidance cues.

Glaser T, Brose C, Franceschini I, Hamann K, Smorodchenko A, Zipp F, Dubois-Dalcq M, Brüstle O.

Stem Cells. 2007 Dec;25(12):3016-25.


Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene.

d'Anglemont de Tassigny X, Fagg LA, Dixon JP, Day K, Leitch HG, Hendrick AG, Zahn D, Franceschini I, Caraty A, Carlton MB, Aparicio SA, Colledge WH.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10714-9.


Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha.

Franceschini I, Lomet D, Cateau M, Delsol G, Tillet Y, Caraty A.

Neurosci Lett. 2006 Jul 3;401(3):225-30.


Schwann cells genetically engineered to express PSA show enhanced migratory potential without impairment of their myelinating ability in vitro.

Lavdas AA, Franceschini I, Dubois-Dalcq M, Matsas R.

Glia. 2006 Jun;53(8):868-78.


Effect of genetically modified Schwann cells with increased motility in end-to-side nerve grafting.

Gravvanis AI, Lavdas A, Papalois AE, Franceschini I, Tsoutsos DA, Dubois-Dalcq M, Matsas R, Ioannovich JD.

Microsurgery. 2005;25(5):423-32.


Migrating and myelinating potential of neural precursors engineered to overexpress PSA-NCAM.

Franceschini I, Vitry S, Padilla F, Casanova P, Tham TN, Fukuda M, Rougon G, Durbec P, Dubois-Dalcq M.

Mol Cell Neurosci. 2004 Oct;27(2):151-62.


Biosynthesis of HNK-1 glycans on O-linked oligosaccharides attached to the neural cell adhesion molecule (NCAM): the requirement for core 2 beta 1,6-N-acetylglucosaminyltransferase and the muscle-specific domain in NCAM.

Ong E, Suzuki M, Belot F, Yeh JC, Franceschini I, Angata K, Hindsgaul O, Fukuda M.

J Biol Chem. 2002 May 17;277(20):18182-90.


Efficient gene transfer in mouse neural precursors with a bicistronic retroviral vector.

Franceschini IA, Feigenbaum-Lacombe V, Casanova P, Lopez-Lastra M, Darlix JL, Dalcq MD.

J Neurosci Res. 2001 Aug 1;65(3):208-19.


Polysialyltransferase ST8Sia II (STX) polysialylates all of the major isoforms of NCAM and facilitates neurite outgrowth.

Franceschini I, Angata K, Ong E, Hong A, Doherty P, Fukuda M.

Glycobiology. 2001 Mar;11(3):231-9.


Developmental pattern of expression of the alpha chemokine stromal cell-derived factor 1 in the rat central nervous system.

Tham TN, Lazarini F, Franceschini IA, Lachapelle F, Amara A, Dubois-Dalcq M.

Eur J Neurosci. 2001 Mar;13(5):845-56.


Adhesion molecule expression and phenotype of glial cells in the olfactory tract.

Barnett SC, Franceschini IA.

Adv Exp Med Biol. 1999;468:297-307.


Neuregulin is a mitogen and survival factor for olfactory bulb ensheathing cells and an isoform is produced by astrocytes.

Pollock GS, Franceschini IA, Graham G, Marchionni MA, Barnett SC.

Eur J Neurosci. 1999 Mar;11(3):769-80.


Schwann cell-like myelination following transplantation of an olfactory bulb-ensheathing cell line into areas of demyelination in the adult CNS.

Franklin RJ, Gilson JM, Franceschini IA, Barnett SC.

Glia. 1996 Jul;17(3):217-24.


Low-affinity NGF-receptor and E-N-CAM expression define two types of olfactory nerve ensheathing cells that share a common lineage.

Franceschini IA, Barnett SC.

Dev Biol. 1996 Jan 10;173(1):327-43.