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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal Tours university CNRS IFCE NMR

Neuroendocrinologie Moleculaire de la Reproduction




I’m a specialist of biological rhythms, with expertise in neuroendocrinology, molecular biology and cell biology. After being awarded a PhD in Neuroscience form Strasbourg University (France, 2003), I did two post-doctoral trainings in Montreal (Canada 2003-2006) and Aberdeen (Scotland 2006-2011), working on the molecular underpinnings of circadian rhythms (i.e. clock genes) and the role of melatonin and the pars tuberalis of the pituitary in seasonal rhythms, respectively. I currently hold a permanent research position at INRA (France) where I keep on working on the molecular and neuroendocrine basis of seasonal and circannual rhythms in sheep

Linck to scholar
Linck to researchgate

Publications :

Discontinuity in the molecular neuroendocrine response to increasing daylengths in Ile-de-France ewes: Is transient Dio2 induction a key feature of circannual timing?

Dardente H, Lomet D, Chesneau D, Pellicer-Rubio MT, Hazlerigg D.

J Neuroendocrinol. 2019 Aug;31(8):e12775.


An integrative view of mammalian seasonal neuroendocrinology.

Dardente H, Wood S, Ebling F, Sáenz de Miera C.

J Neuroendocrinol. 2019 May;31(5):e12729.


Brain mapping of the gonadotropin-inhibitory hormone-related peptide 2 with a novel antibody suggests a connection with emotional reactivity in the Japanese quail (Coturnix japonica, Temminck & Schlegel, 1849).

Poissenot K, Anger K, Constantin P, Cornilleau F, Lomet D, Tsutsui K, Dardente H, Calandreau L, Beltramo M.

J Comp Neurol. 2019 Aug 1;527(11):1872-1884.


Photoperiod and thyroid hormone regulate expression of L‐Dopachrome tautomerase (Dct), a melanocyte stem‐cell marker, in tanycytes of the ovine hypothalamus

H Dardente, D Lomet

Journal of neuroendocrinology, e12640


Neuroendocrine correlates of the critical day length response in the Soay sheep

D Hazlerigg, D Lomet, G Lincoln, H Dardente

Journal of neuroendocrinology, e12631


Anti-angiogenic VEGFAxxxb transcripts are not expressed in the medio-basal hypothalamus of the seasonal sheep

D Lomet, B Piégu, SH Wood, H Dardente

PloS one 13 (5), e0197123


The impact of thyroid hormone in seasonal breeding has a restricted transcriptional signature

D Lomet, J Cognié, D Chesneau, E Dubois, D Hazlerigg, H Dardente

Cellular and Molecular Life Sciences 75 (5), 905-919


Effects of photoperiod extension on clock gene and neuropeptide RNA expression in the SCN of the Soay sheep

H Dardente, CA Wyse, GA Lincoln, GC Wagner, DG Hazlerigg

PloS one 11 (7), e0159201


Seasonal breeding in mammals: From basic science to applications and back

H Dardente, D Lomet, V Robert, C Decourt, M Beltramo, ...

Theriogenology 86 (1), 324-332


A synthetic kisspeptin analog that triggers ovulation and advances puberty

C Decourt, V Robert, K Anger, M Galibert, JB Madinier, X Liu, H Dardente, ...

Scientific reports 6, 26908


Contrôle neuroendocrinien de la reproduction chez les mammifères

M Migaud, H Dardente, M Keller, M Batailler, M Meurisse, D Pillon

INRA Productions Animales 29 (4), 255-266


Circannual biology: the double life of the seasonal thyrotroph

H Dardente

Current Biology 25 (20), R988-R991


Rational design of triazololipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotropins

M Beltramo, V Robert, M Galibert, JB Madinier, P Marceau, H Dardente, ...

Journal of medicinal chemistry 58 (8), 3459-3470


Functional divergence of type 2 deiodinase paralogs in the Atlantic salmon

M Lorgen, E Casadei, E Król, A Douglas, MJ Birnie, LOE Ebbesson,H Dardente ...

Current Biology 25 (7), 936-941


Seasonal timing: how does a hibernator know when to stop hibernating?

RA Hut, H Dardente, SJ Riede

Current Biology 24 (13), R602-R605


Thyroid hormone and seasonal rhythmicity

H Dardente, DG Hazlerigg, FJP Ebling

Frontiers in endocrinology 5, 19


Acute injection and chronic perfusion of kisspeptin elicit gonadotropins release but fail to trigger ovulation in the mare

C Decourt, A Caraty, C Briant, D Guillaume, D Lomet, D Chesneau, H Dardente ...

Biology of reproduction 90 (2)


Cellular mechanisms and integrative timing of neuroendocrine control of GnRH secretion by kisspeptin

M Beltramo, H Dardente, X Cayla, A Caraty

Molecular and cellular endocrinology 382 (1), 387-399


BDNF parabrachio-amygdaloid pathway in morphine-induced analgesia

M Sarhan, SA Pawlowski, F Barthas, I Yalcin, J Kaufling, H Dardente, ...

International Journal of Neuropsychopharmacology 16 (7), 1649-1660


Analysis of core circadian feedback loop in suprachiasmatic nucleus of mCry1-luc transgenic reporter mouse

ES Maywood, L Drynan, JE Chesham, MD Edwards, H Dardente, ...

Proceedings of the National Academy of Sciences 110 (23), 9547-9552


Photoperiodic variation in CD45-positive cells and cell proliferation in the mediobasal hypothalamus of the Soay sheep

DG Hazlerigg, CA Wyse, H Dardente, EA Hanon, GA Lincoln

Chronobiology international 30 (4), 548-558


Circannual Variation in Thyroid Hormone Deiodinases in a Short‐Day Breeder

C Saenz de Miera, EA Hanon, H Dardente, M Birnie, V Simonneaux, ...

Journal of neuroendocrinology 25 (4), 412-421


Strong pituitary and hypothalamic responses to photoperiod but not to 6-methoxy-2-benzoxazolinone in female common voles (Microtus arvalis)

E Król, A Douglas, H Dardente, MJ Birnie, V Van Der Vinne, WG Eijer, ...

General and comparative endocrinology 179 (2), 289-295


The nuclear receptor REV-ERBα is required for the daily balance of carbohydrate and lipid metabolism

J Delezie, S Dumont, H Dardente, H Oudart, A Gréchez-Cassiau, ...

The FASEB Journal 26 (8), 3321-3335


Melatonin‐Dependent Timing of Seasonal Reproduction by the Pars Tuberalis: Pivotal Roles for Long Daylengths and Thyroid Hormones

H Dardente

Journal of neuroendocrinology 24 (2), 249-266


Circadian variation of the response of T cells to antigen

EE Fortier, J Rooney, H Dardente, MP Hardy, N Labrecque, N Cermakian

The Journal of Immunology, 1004030


Evidence for RGS4 modulation of melatonin and thyrotrophin signalling pathways in the pars tuberalis

SM Dupré, H Dardente, MJ Birnie, ASI Loudon, GA Lincoln, DG Hazlerigg

Journal of neuroendocrinology 23 (8), 725-732


A molecular switch for photoperiod responsiveness in mammals

H Dardente, CA Wyse, MJ Birnie, SM Dupré, ASI Loudon, GA Lincoln, ...

Current Biology 20 (24), 2193-2198


Effect of Photoperiod on the Thyroid‐Stimulating Hormone Neuroendocrine System in the European Hamster (Cricetus cricetus)

EA Hanon, K Routledge, H Dardente, M Masson‐Pévet, PJ Morgan, ...

Journal of neuroendocrinology 22 (1), 51-55


Neurogenetics of food anticipation

E Challet, J Mendoza, H Dardente, P Pévet

European Journal of Neuroscience 30 (9), 1676-1687


Transcriptional feedback loops in the ovine circadian clock

H Dardente, JM Fustin, DG Hazlerigg

Comparative Biochemistry and Physiology Part A: Molecular & Integrative …


Egr1 involvement in evening gene regulation by melatonin

JM Fustin, H Dardente, GC Wagner, DA Carter, JD Johnston, GA Lincoln, ...

The FASEB Journal 23 (3), 764-773


Cry1 Circadian Phase in vitro: Wrapped Up with an E-Box

JM Fustin, JS O'Neill, MH Hastings, DG Hazlerigg, H Dardente

Journal of biological rhythms 24 (1), 16-24


Clock‐dependent and independent transcriptional control of the two isoforms from the mouse Rorγgene

V Mongrain, X Ruan, H Dardente, EE Fortier, N Cermakian

Genes to Cells 13 (12), 1197-1210


RFamide‐related peptide and its cognate receptor in the sheep: cDNA cloning, mRNA distribution in the hypothalamus and the effect of photoperiod

H Dardente, M Birnie, GA Lincoln, DG Hazlerigg

Journal of neuroendocrinology 20 (11), 1252-1259


Implication of the F-Box Protein FBXL21 in circadian pacemaker function in mammals

H Dardente, J Mendoza, JM Fustin, E Challet, DG Hazlerigg

PLoS One 3 (10), e3530


Ancestral TSH mechanism signals summer in a photoperiodic mammal

EA Hanon, GA Lincoln, JM Fustin, H Dardente, M Masson-Pévet, ...

Current Biology 18 (15), 1147-1152


Synchronization and genetic redundancy in circadian clocks

H Dardente

Medecine sciences: M/S 24 (3), 270-276


The circadian clock stops ticking during deep hibernation in the European hamster

FG Revel, A Herwig, ML Garidou, H Dardente, JS Menet, M Masson-Pévet, ...

Proceedings of the National Academy of Sciences 104 (34), 13816-13820


Does a melatonin‐dependent circadian oscillator in the pars tuberalis drive prolactin seasonal rhythmicity?

H Dardente

Journal of neuroendocrinology 19 (8), 657-666


Expression of TGFα in the suprachiasmatic nuclei of nocturnal and diurnal rodents

BB Tournier, H Dardente, P Vuillez, P Pevet, E Challet

Neuroscience 145 (3), 1138-1143


Cryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression

H Dardente, EE Fortier, V Martineau, N Cermakian

Biochemical Journal 402 (3), 525-536


Seasonal variations of clock gene expression in the suprachiasmatic nuclei and pars tuberalis of the European hamster (Cricetus cricetus)

BB Tournier, H Dardente, V Simonneaux, B Vivien‐Roels, P Pévet, ...

European Journal of Neuroscience 25 (5), 1529-1536


Molecular circadian rhythms in central and peripheral clocks in mammals

H Dardente, H Dardente, N Cermakian

Chronobiology international 24 (2), 195-213


Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors

F Guillaumond, H Dardente, V Giguère, N Cermakian

Journal of biological rhythms 20 (5), 391-403


Timed hypocaloric feeding and melatonin synchronize the suprachiasmatic clockwork in rats, but with opposite timing of behavioral output

I Caldelas, CA Feillet, H Dardente, F Eclancher, A Malan, S Gourmelen, ...

European Journal of Neuroscience 22 (4), 921-929


Tissue‐specific expression of tryptophan hydroxylase mRNAs in the rat midbrain: anatomical evidence and daily profiles

ZS Malek, H Dardente, P Pevet, S Raison

European Journal of Neuroscience 22 (4), 895-901


Feeding cues alter clock gene oscillations and photic responses in the suprachiasmatic nuclei of mice exposed to a light/dark cycle

J Mendoza, C Graff, H Dardente, P Pevet, E Challet

Journal of Neuroscience 25 (6), 1514-1522


How many pieces to build a circadian clock?

H Dardente, N Cermakian

Medecine sciences: M/S 21 (1), 66-72


Daily and circadian expression of neuropeptides in the suprachiasmatic nuclei of nocturnal and diurnal rodents

H Dardente, JS Menet, E Challet, BB Tournier, P Pévet, M Masson-Pévet

Molecular Brain Research 124 (2), 143-151


Dark pulse resetting of the suprachiasmatic clock in Syrian hamsters: behavioral phase-shifts and clock gene expression

JY Mendoza, H Dardente, C Escobar, P Pevet, E Challet

Neuroscience 127 (2), 529-537


Contrary to other non-photic cues, acute melatonin injection does not induce immediate changes of clock gene mRNA expression in the rat suprachiasmatic nuclei

VJ Poirel, V Boggio, H Dardente, P Pevet, M Masson-Pevet, F Gauer

Neuroscience 120 (3), 745-755


MT1 melatonin receptor mRNA expressing cells in the pars tuberalis of the European hamster: effect of photoperiod

H Dardente, P Klosen, P Pevet, M Masson‐Pevet

Journal of neuroendocrinology 15 (8), 778-786


Melatonin induces Cry1 expression in the pars tuberalis of the rat

H Dardente, JS Menet, VJ Poirel, D Streicher, F Gauer, B Vivien-Roels, ...

Molecular brain research 114 (2), 101-106


Photoperiod differentially regulates clock genes’ expression in the suprachiasmatic nucleus of Syrian hamster

BB Tournier, JS Menet, H Dardente, VJ Poirel, A Malan, M Masson-Pevet, ...

Neuroscience 118 (2), 317-322


Expression and regulation of Icer mRNA in the Syrian hamster pineal gland

E Diaz, ML Garidou, H Dardente, A Salingre, P Pevet, V Simonneaux

Molecular brain research 112 (1-2), 163-169


Per and neuropeptide expression in the rat suprachiasmatic nuclei: compartmentalization and differential cellular induction by light

H Dardente, VJ Poirel, P Klosen, P Pevet, M Masson-Pevet

Brain research 958 (2), 261-271


The mt1 melatonin receptor and RORβ receptor are co-localized in specific TSH-immunoreactive cells in the pars tuberalis of the rat pituitary

P Klosen, C Bienvenu, O Demarteau, H Dardente, H Guerrero, P Pévet, ...

Journal of Histochemistry & Cytochemistry 50 (12), 1647-1657


Phenotype of Per1- and Per2-expressing neurons in the suprachiasmatic nucleus of a diurnal rodent (Arvicanthis ansorgei): comparison with a nocturnal species …

H Dardente, P Klosen, I Caldelas, P Pévet, M Masson-Pévet

Cell and tissue research 310 (1), 85-92