Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free: https://www.ghostery.com/fr/products/

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site: http://www.youronlinechoices.com/fr/controler-ses-cookies/, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Realytics
Google Analytics
Spoteffects
Optimizely

Targeted advertising cookies

DoubleClick
Mediarithmics

The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at cil-dpo@inra.fr or by post at:

INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal Tours university CNRS IFCE NMR

Neuroendocrinologie Moleculaire de la Reproduction

Hugues DARDENTE

CR1 - HDR

Hugues DARDENTE
© INRA

I’m a specialist of biological rhythms, with expertise in neuroendocrinology, molecular biology and cell biology. After being awarded a PhD in Neuroscience form Strasbourg University (France, 2003), I did two post-doctoral trainings in Montreal (Canada 2003-2006) and Aberdeen (Scotland 2006-2011), working on the molecular underpinnings of circadian rhythms (i.e. clock genes) and the role of melatonin and the pars tuberalis of the pituitary in seasonal rhythms, respectively. I currently hold a permanent research position at INRA (France) where I keep on working on the molecular and neuroendocrine basis of seasonal and circannual rhythms in sheep

Linck to scholar
Linck to researchgate

Publications :

Discontinuity in the molecular neuroendocrine response to increasing daylengths in Ile-de-France ewes: Is transient Dio2 induction a key feature of circannual timing?

Dardente H, Lomet D, Chesneau D, Pellicer-Rubio MT, Hazlerigg D.

J Neuroendocrinol. 2019 Aug;31(8):e12775.

2019

An integrative view of mammalian seasonal neuroendocrinology.

Dardente H, Wood S, Ebling F, Sáenz de Miera C.

J Neuroendocrinol. 2019 May;31(5):e12729.

2019

Brain mapping of the gonadotropin-inhibitory hormone-related peptide 2 with a novel antibody suggests a connection with emotional reactivity in the Japanese quail (Coturnix japonica, Temminck & Schlegel, 1849).

Poissenot K, Anger K, Constantin P, Cornilleau F, Lomet D, Tsutsui K, Dardente H, Calandreau L, Beltramo M.

J Comp Neurol. 2019 Aug 1;527(11):1872-1884.

2019

Photoperiod and thyroid hormone regulate expression of L‐Dopachrome tautomerase (Dct), a melanocyte stem‐cell marker, in tanycytes of the ovine hypothalamus

H Dardente, D Lomet

Journal of neuroendocrinology, e12640

2018

Neuroendocrine correlates of the critical day length response in the Soay sheep

D Hazlerigg, D Lomet, G Lincoln, H Dardente

Journal of neuroendocrinology, e12631

2018

Anti-angiogenic VEGFAxxxb transcripts are not expressed in the medio-basal hypothalamus of the seasonal sheep

D Lomet, B Piégu, SH Wood, H Dardente

PloS one 13 (5), e0197123

2018

The impact of thyroid hormone in seasonal breeding has a restricted transcriptional signature

D Lomet, J Cognié, D Chesneau, E Dubois, D Hazlerigg, H Dardente

Cellular and Molecular Life Sciences 75 (5), 905-919

2018

Effects of photoperiod extension on clock gene and neuropeptide RNA expression in the SCN of the Soay sheep

H Dardente, CA Wyse, GA Lincoln, GC Wagner, DG Hazlerigg

PloS one 11 (7), e0159201

2016

Seasonal breeding in mammals: From basic science to applications and back

H Dardente, D Lomet, V Robert, C Decourt, M Beltramo, ...

Theriogenology 86 (1), 324-332

2016

A synthetic kisspeptin analog that triggers ovulation and advances puberty

C Decourt, V Robert, K Anger, M Galibert, JB Madinier, X Liu, H Dardente, ...

Scientific reports 6, 26908

2016

Contrôle neuroendocrinien de la reproduction chez les mammifères

M Migaud, H Dardente, M Keller, M Batailler, M Meurisse, D Pillon

INRA Productions Animales 29 (4), 255-266

2016

Circannual biology: the double life of the seasonal thyrotroph

H Dardente

Current Biology 25 (20), R988-R991

2015

Rational design of triazololipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotropins

M Beltramo, V Robert, M Galibert, JB Madinier, P Marceau, H Dardente, ...

Journal of medicinal chemistry 58 (8), 3459-3470

2015

Functional divergence of type 2 deiodinase paralogs in the Atlantic salmon

M Lorgen, E Casadei, E Król, A Douglas, MJ Birnie, LOE Ebbesson,H Dardente ...

Current Biology 25 (7), 936-941

2015

Seasonal timing: how does a hibernator know when to stop hibernating?

RA Hut, H Dardente, SJ Riede

Current Biology 24 (13), R602-R605

2014

Thyroid hormone and seasonal rhythmicity

H Dardente, DG Hazlerigg, FJP Ebling

Frontiers in endocrinology 5, 19

2014

Acute injection and chronic perfusion of kisspeptin elicit gonadotropins release but fail to trigger ovulation in the mare

C Decourt, A Caraty, C Briant, D Guillaume, D Lomet, D Chesneau, H Dardente ...

Biology of reproduction 90 (2)

2014

Cellular mechanisms and integrative timing of neuroendocrine control of GnRH secretion by kisspeptin

M Beltramo, H Dardente, X Cayla, A Caraty

Molecular and cellular endocrinology 382 (1), 387-399

2014

BDNF parabrachio-amygdaloid pathway in morphine-induced analgesia

M Sarhan, SA Pawlowski, F Barthas, I Yalcin, J Kaufling, H Dardente, ...

International Journal of Neuropsychopharmacology 16 (7), 1649-1660

2013

Analysis of core circadian feedback loop in suprachiasmatic nucleus of mCry1-luc transgenic reporter mouse

ES Maywood, L Drynan, JE Chesham, MD Edwards, H Dardente, ...

Proceedings of the National Academy of Sciences 110 (23), 9547-9552

2013

Photoperiodic variation in CD45-positive cells and cell proliferation in the mediobasal hypothalamus of the Soay sheep

DG Hazlerigg, CA Wyse, H Dardente, EA Hanon, GA Lincoln

Chronobiology international 30 (4), 548-558

2013

Circannual Variation in Thyroid Hormone Deiodinases in a Short‐Day Breeder

C Saenz de Miera, EA Hanon, H Dardente, M Birnie, V Simonneaux, ...

Journal of neuroendocrinology 25 (4), 412-421

2013

Strong pituitary and hypothalamic responses to photoperiod but not to 6-methoxy-2-benzoxazolinone in female common voles (Microtus arvalis)

E Król, A Douglas, H Dardente, MJ Birnie, V Van Der Vinne, WG Eijer, ...

General and comparative endocrinology 179 (2), 289-295

2012

The nuclear receptor REV-ERBα is required for the daily balance of carbohydrate and lipid metabolism

J Delezie, S Dumont, H Dardente, H Oudart, A Gréchez-Cassiau, ...

The FASEB Journal 26 (8), 3321-3335

2012

Melatonin‐Dependent Timing of Seasonal Reproduction by the Pars Tuberalis: Pivotal Roles for Long Daylengths and Thyroid Hormones

H Dardente

Journal of neuroendocrinology 24 (2), 249-266

2012

Circadian variation of the response of T cells to antigen

EE Fortier, J Rooney, H Dardente, MP Hardy, N Labrecque, N Cermakian

The Journal of Immunology, 1004030

2011

Evidence for RGS4 modulation of melatonin and thyrotrophin signalling pathways in the pars tuberalis

SM Dupré, H Dardente, MJ Birnie, ASI Loudon, GA Lincoln, DG Hazlerigg

Journal of neuroendocrinology 23 (8), 725-732

2011

A molecular switch for photoperiod responsiveness in mammals

H Dardente, CA Wyse, MJ Birnie, SM Dupré, ASI Loudon, GA Lincoln, ...

Current Biology 20 (24), 2193-2198

2010

Effect of Photoperiod on the Thyroid‐Stimulating Hormone Neuroendocrine System in the European Hamster (Cricetus cricetus)

EA Hanon, K Routledge, H Dardente, M Masson‐Pévet, PJ Morgan, ...

Journal of neuroendocrinology 22 (1), 51-55

2010

Neurogenetics of food anticipation

E Challet, J Mendoza, H Dardente, P Pévet

European Journal of Neuroscience 30 (9), 1676-1687

2009

Transcriptional feedback loops in the ovine circadian clock

H Dardente, JM Fustin, DG Hazlerigg

Comparative Biochemistry and Physiology Part A: Molecular & Integrative …

2009

Egr1 involvement in evening gene regulation by melatonin

JM Fustin, H Dardente, GC Wagner, DA Carter, JD Johnston, GA Lincoln, ...

The FASEB Journal 23 (3), 764-773

2009

Cry1 Circadian Phase in vitro: Wrapped Up with an E-Box

JM Fustin, JS O'Neill, MH Hastings, DG Hazlerigg, H Dardente

Journal of biological rhythms 24 (1), 16-24

2009

Clock‐dependent and independent transcriptional control of the two isoforms from the mouse Rorγgene

V Mongrain, X Ruan, H Dardente, EE Fortier, N Cermakian

Genes to Cells 13 (12), 1197-1210

2008

RFamide‐related peptide and its cognate receptor in the sheep: cDNA cloning, mRNA distribution in the hypothalamus and the effect of photoperiod

H Dardente, M Birnie, GA Lincoln, DG Hazlerigg

Journal of neuroendocrinology 20 (11), 1252-1259

2008

Implication of the F-Box Protein FBXL21 in circadian pacemaker function in mammals

H Dardente, J Mendoza, JM Fustin, E Challet, DG Hazlerigg

PLoS One 3 (10), e3530

2008

Ancestral TSH mechanism signals summer in a photoperiodic mammal

EA Hanon, GA Lincoln, JM Fustin, H Dardente, M Masson-Pévet, ...

Current Biology 18 (15), 1147-1152

2008

Synchronization and genetic redundancy in circadian clocks

H Dardente

Medecine sciences: M/S 24 (3), 270-276

2008

The circadian clock stops ticking during deep hibernation in the European hamster

FG Revel, A Herwig, ML Garidou, H Dardente, JS Menet, M Masson-Pévet, ...

Proceedings of the National Academy of Sciences 104 (34), 13816-13820

2007

Does a melatonin‐dependent circadian oscillator in the pars tuberalis drive prolactin seasonal rhythmicity?

H Dardente

Journal of neuroendocrinology 19 (8), 657-666

2007

Expression of TGFα in the suprachiasmatic nuclei of nocturnal and diurnal rodents

BB Tournier, H Dardente, P Vuillez, P Pevet, E Challet

Neuroscience 145 (3), 1138-1143

2007

Cryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression

H Dardente, EE Fortier, V Martineau, N Cermakian

Biochemical Journal 402 (3), 525-536

2007

Seasonal variations of clock gene expression in the suprachiasmatic nuclei and pars tuberalis of the European hamster (Cricetus cricetus)

BB Tournier, H Dardente, V Simonneaux, B Vivien‐Roels, P Pévet, ...

European Journal of Neuroscience 25 (5), 1529-1536

2007

Molecular circadian rhythms in central and peripheral clocks in mammals

H Dardente, H Dardente, N Cermakian

Chronobiology international 24 (2), 195-213

2007

Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors

F Guillaumond, H Dardente, V Giguère, N Cermakian

Journal of biological rhythms 20 (5), 391-403

2005

Timed hypocaloric feeding and melatonin synchronize the suprachiasmatic clockwork in rats, but with opposite timing of behavioral output

I Caldelas, CA Feillet, H Dardente, F Eclancher, A Malan, S Gourmelen, ...

European Journal of Neuroscience 22 (4), 921-929

2005

Tissue‐specific expression of tryptophan hydroxylase mRNAs in the rat midbrain: anatomical evidence and daily profiles

ZS Malek, H Dardente, P Pevet, S Raison

European Journal of Neuroscience 22 (4), 895-901

2005

Feeding cues alter clock gene oscillations and photic responses in the suprachiasmatic nuclei of mice exposed to a light/dark cycle

J Mendoza, C Graff, H Dardente, P Pevet, E Challet

Journal of Neuroscience 25 (6), 1514-1522

2005

How many pieces to build a circadian clock?

H Dardente, N Cermakian

Medecine sciences: M/S 21 (1), 66-72

2005

Daily and circadian expression of neuropeptides in the suprachiasmatic nuclei of nocturnal and diurnal rodents

H Dardente, JS Menet, E Challet, BB Tournier, P Pévet, M Masson-Pévet

Molecular Brain Research 124 (2), 143-151

2004

Dark pulse resetting of the suprachiasmatic clock in Syrian hamsters: behavioral phase-shifts and clock gene expression

JY Mendoza, H Dardente, C Escobar, P Pevet, E Challet

Neuroscience 127 (2), 529-537

2004

Contrary to other non-photic cues, acute melatonin injection does not induce immediate changes of clock gene mRNA expression in the rat suprachiasmatic nuclei

VJ Poirel, V Boggio, H Dardente, P Pevet, M Masson-Pevet, F Gauer

Neuroscience 120 (3), 745-755

2003

MT1 melatonin receptor mRNA expressing cells in the pars tuberalis of the European hamster: effect of photoperiod

H Dardente, P Klosen, P Pevet, M Masson‐Pevet

Journal of neuroendocrinology 15 (8), 778-786

2003

Melatonin induces Cry1 expression in the pars tuberalis of the rat

H Dardente, JS Menet, VJ Poirel, D Streicher, F Gauer, B Vivien-Roels, ...

Molecular brain research 114 (2), 101-106

2003

Photoperiod differentially regulates clock genes’ expression in the suprachiasmatic nucleus of Syrian hamster

BB Tournier, JS Menet, H Dardente, VJ Poirel, A Malan, M Masson-Pevet, ...

Neuroscience 118 (2), 317-322

2003

Expression and regulation of Icer mRNA in the Syrian hamster pineal gland

E Diaz, ML Garidou, H Dardente, A Salingre, P Pevet, V Simonneaux

Molecular brain research 112 (1-2), 163-169

2003

Per and neuropeptide expression in the rat suprachiasmatic nuclei: compartmentalization and differential cellular induction by light

H Dardente, VJ Poirel, P Klosen, P Pevet, M Masson-Pevet

Brain research 958 (2), 261-271

2002

The mt1 melatonin receptor and RORβ receptor are co-localized in specific TSH-immunoreactive cells in the pars tuberalis of the rat pituitary

P Klosen, C Bienvenu, O Demarteau, H Dardente, H Guerrero, P Pévet, ...

Journal of Histochemistry & Cytochemistry 50 (12), 1647-1657

2002

Phenotype of Per1- and Per2-expressing neurons in the suprachiasmatic nucleus of a diurnal rodent (Arvicanthis ansorgei): comparison with a nocturnal species …

H Dardente, P Klosen, I Caldelas, P Pévet, M Masson-Pévet

Cell and tissue research 310 (1), 85-92

2002