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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal Tours university CNRS IFCE

Neuroendocrinologie Moleculaire de la Reproduction

Emmanuel MOYSE


Emmanuel MOYSE

My doctoral and post-doctoral formations, and half of my published articles, concern characterization and localization of receptors for chemical extracellular mediators by radioligand binding and autoradiography, from the macroscopic scale to electron microscopy. I addressed then programmed cell death and neuron neogenesis in adult mammalian brain as effector mechanisms of the neuroplasticity processes underlying physiological adaptations of neural functions. My present research topic aims at understanding the biological role of the neural stem cells of the satiety reflex center of adult rodents (dorsal vagal complex) in reproduction-nutrition interactions. This continuous activity has provided 65 published articles, 14 doctoral thesis and 41 Mastere internships (M1 or M2).


Masteres de Biologie de l’Université de Tours : coordination et enseignements présentiels dans l’UE mutualisée « Cellules-souches » des M1 de Biologie-Santé et de Biologie de la Reproduction.

Cours de Neuroendocrinologie dans le M1 « BioRepro » de Tours et dans le M2 d’Endocrinologie de Paris-XI.

Coordination du M2 de Biologie du Vieillissement des Universités Paris-Diderot et Paris-Descartes.

Linck to researchgate



Brain region-specific effects of long-term caloric restriction on redox balance of the aging rat.

Moyse E, Arseneault M, Ferland G, Gaudreau P, Ramassamy C

Mech Ageing Dev 2019 179:51-9.


Leptin-dependent neurotoxicity via induction of apoptosis in adult rat neurogenic cells.

Segura S, Efthimiadi L, Porchet C, Courtes S, Tardivel C, Coronas V, Krantic S, Moyse E

Front. Cell. Neurosci. 2015 9:350.


Gender- and region-dependent changes of redox biomarkers in the brain of successfully aging LOU/C rats.

Moyse E, Arseneault M, Ferland G, Gaudreau P, Ramassamy C

Mech. Ageing Dev. 2015 149:19-30.


Rod-derived cone viability factor acts by stimulating aerobic glycolysis.

Aït-Ali N, Fridlich R, Millet-Puel G, Clérin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, Dalkara D, van Dorsselaer A, Sahel JA, Léveillard T

Cell 2015 161(4):817-32.


Aging, but not Tau pathology, impacts olfactory performances and somatostatin systems in mice.

Martel G, Simon A, Nocera S, Kalainathan S, Pidoux L, Blum D, Leclère-Thurbant S, Diaz J, Geny D, Moyse E, Videau C, Buée L, Epelbaum J, Viollet C

Neurobiol Aging 2015 36(2):1013-28.


Modulation of orexigenic and anorexigenic peptides gene expression in the rat DVC and hypothalamus by acute immobilization stress.

Chigr F, Rachidi F, Tardivel C, Najimi M, Moyse E

Front Cell Neurosci 2014 8 :198.


Effects of age and calory restriction on brainstem satiety centre signals in rat.

Moyse E, Bedard K, Segura S, Mahaut S, Tardivel C, Ferland G, Lebrun B, Gaudreau P

Mech. Ageing Dev. 2012 133(2-3):83-91.


Inactivation of Socs3 in the hypothalamus enhances the hindbrain response to endogenous satiety signals via oxytocin signaling.

Matarazzo V, Schaller F, Nedelec E, Benani A, Pénicaud L, Muscatelli F, Moyse E, Bauer S

J. Neurosci. 2012 32(48):17097-107.


Hippocampal GABAergic neurons are susceptible to amyloid beta toxicity in vitro and are decreased in number in the Alzheimer’s disease TgCRND8 mouse model.

Krantic S, Isorce N, Mechawar N, Davoli MA, Vignault E, Albuquerque M, Chabot JG, Moyse E, Chauvin JP, Aubert I, McLaurin JA, Quirion R

J. Alzheimer’s Dis. 2012 29(2):293-308.


Adult brain-derived neural stem cells grafting into a vein bridge increases post-lesional recovery and regeneration in a peripheral nerve of adult pig.

Liard O, Segura S, Sagui E, Nau A, Pascual A, Cambon M, Darlix JL, Fusai T, Moyse E

Stem Cells Int. 2012:128732. doi: 10.1155/2012/128732.


Neuropeptide Y receptor subtypes in the dorsal vagal complex under acute feeding adaptation in the adult rat.

Mahaut S, Dumont Y, Fournier A, Quirion R, Moyse E

Neuropeptides 2010 44:77-86.


A positive change in energy balance modulates TrkB expression in the hypothalamus and nodose ganglia of rats.

Zeeni N, Chaumontet C, Moyse E, Fromentin G, Tardivel C, Tome D, Jean A, Darcel N

Brain Res. 2009 1289:49-55.


In vitro isolation of neural precursor cells from the adult pig subventricular zone.

Liard O, Segura S, Pascual A, Gaudreau P, Fusai T, Moyse E

J. Neurosci. Methods 2009 182(2):172-179.


Neurogenesis inhibition by chronic immobilization stress in the dorsal vagal complex of adult rat.

Chigr F, Rachidi F, Segura S, Mahaut S, Tardivel C, Jean A, Najimi M, Moyse E

Neuroscience 2009 158:524-536.



Control of proliferation and lineage commitment in adult neural stem cells by tissular microenvironment in healthy and post-lesional conditions.

Moyse E, Segura S, Liard O, Mahaut S, Mechawar N

Current Stem Cell Research and Therapy 2008 3(3):163-184.


Distribution of peripherally injected Peptide YY ([125I] PYY(3-36)) and Pancreatic Polypeptide ([125I]hPP) in the CNS: enrichment in the Area Postrema.

Dumont Y, Moyse E, Fournier A, Quirion R

J. Mol. Neurosci. 2007 33(3):294-304.


Leptin-mediated decrease of cyclin A2 and increase of cyclin D1 expressions: relevance for the control of prepubertal rat Leydig cell division and differentiation.

Fombonne J, Charrier C, Goddard I, Moyse E, Krantic S

Endocrinology 2007148(5):2126-37.


Glial fibrillary acidic protein (GFAP)-expressing cells exhibiting a radial morphology are present in the nucleus of the solitary tract of adult rat.

Pecchi E, Dallaporta M, Charrier C, Pio J, Jean A, Moyse E, Troadec JD

J. Comp. Neurol. 2007 501(3):353-368.


BDNF regulation in the rat Dorsal Vagal Complex during stress-induced anorexia.

Charrier C, Chigr F, Tardivel C, Mahaut S, Jean A, Najimi M, Moyse E

Brain Res. 2006 1107(1):52-57.



Characterization of neural stem cells in the dorsal vagal complex of adult rat brainstem by in vivo proliferation labelling and in vitro neurosphere assay.

Charrier C, Coronas V, Fombonne J, Roger M, Jean A, Krantic S, Moyse E

Neuroscience 2006 138(1):5-16. 


BDNF plays a role as an anorexigenic factor in the dorsal vagal complex.

Bariohay B, Lebrun B, Moyse E, Jean A

Endocrinology 2005 146(12):5612-5620.


Evidence for the existence of an additional class of neuropeptide Y receptor sites in the rat brain.

Dumont Y, Moyse E, Fournier A, Quirion R

J. Pharmacol. Exp. Ther. 2005 315(1):99-108.


In vivo neurogenesis in the dorsal vagal complex of the adult rat brainstem.

Bauer S, Hay M, Amilhon B, Jean A, Moyse E

Neuroscience 2005 130(1):75-90.


Accumulation of Ym1/2 protein in the mouse olfactory epithelium during regeneration and aging.

Giannetti N, Moyse E, Ducray A, Bondier JR, Jourdan F, Kastner A

Neuroscience 2004 123(4):907-917.


Effects of the alpha2-adrenoceptor antagonist, dexefaroxan, on neurogenesis in the olfactory bulb of the adult rat in vivo : selective protection against apoptosis.

Bauer S, Moyse E, Jourdan F, Colpaert F, Martel JC, Marien M

Neuroscience 2003 117:281-291.


Leukemia Inhibitory Factor induction is a key component of lesion-triggered renewal of olfactory sensory neurons in adult mouse.

Bauer S, Rasika S, Mauduit C, Raccurt M, Morel G, Jourdan F, Benahmed M, Moyse E, Patterson PH

J. Neurosci. 2003 23(5):1792-1803.


Serine protease inhibitor Spi2-mediated apoptosis of olfactory neurons.

Thiemmara V, Pays L, Danty E, Jourdan F, Moyse E, Mehlen P

Cell Death Differ. 2002 9(12):1343-51.


Regional distribution of benzodiazepine binding sites in the human newborn and infant hypothalamus. A quantitative autoradiographic study.

Najimi M, Bennis M, Moyse E, Miachon S, Kopp N, Chigr F

Brain Res. 2001 895:129-138.


Immunohistochemical distribution of DSIP immunoreactivity in the human hypothalamus during the first postnatal year. A preliminary report.

Najimi M, Bennis M, Moyse E, Kopp N, Chigr F

Folia Biol (Praha) 2001 47:66-70.


Distribution of delta sleep-inducing peptide in the newborn and infant human hypothalamus: an immunohistochemical study.

Najimi M, Bennis M, Moyse E, Chigr F

Biol. Res. 2001 34 :31-42.


Alteration of the stability of Bag-1 protein in the control of olfactory neuronal apoptosis.

Sourisseau T, Desbois C, Debure L, Bowtell DDL, Catou ACB, Schneikert J, Moyse E, Michel D

J. Cell Sci. 2001 114(Pt7) :1409-1416.


Netrin-1-mediated axonal outgrowth and cAMP production requires interaction with the adenosine A2b receptor.

Corset V, Nguyen-Ba-Charvet KT, Forcet C, Moyse E, Chedotal A, Mehlen P

Nature 2000 407:747-750.


Productive measles virus brain infection and apoptosis in CD46 transgenic mice.

Evlashev A, Moyse E, Valentin H, Azocar O, Trescol-Biemont MC, Marie J, Rabourdin-Combe C, Horvat B

J. Virol. 2000 74: 1373-1382.


Viral mRNAs in middle ear mucosa and exudates during human otitis media with effusion.

Moyse E, Lyon M, Cordier G, Collet L, Mornex JF, Froehlich P

Arch. Otolaryngol. Head Neck Surg. 2000 126: 1105-1110.


Unusual regulation of cyclin-dependent kinases cdk2 and cdk4 during in vivo mitotic stimulation of olfactory neuron progenitors in adult mouse.

Kastner A, Moyse E, Bauer S, Jourdan F, Brun G

J. Neurochem. 2000 74(6): 2343-2349.



Benzodiazepine binding sites in the human hypothalamus: autoradiographic study.

Najimi M, Bennis M, Chigr F, Kopp N, Moyse E, Miachon S

J. Hirnforsch. 1999 39(4):493-502.



Dopamine receptor coupling to adenylyl-cyclase in rat olfactory pathway: a combined pharmacological-radioautographic approach.

Coronas V, Krantic S, Jourdan F, Moyse E

Neuroscience 1999 90(1):69-78.


Olfactory neurons are protected from apoptosis in adult transgenic mice over-expressing the bcl-2 gene.

Jourdan F, Moyse E, DeBilbao F, Dubois-Dauphin M

Neuroreport 1998 9(5):921-926.



Optimization of PCR/lambda exonuclease-mediated synthesis of sense and antisense DNA probes for in situ hybridization.

Michel D, Trembleau A, Moyse E, Brun G

Histochem. J. 1997 29(9):685-693.


Clusterin/ApoJ expression is associated with neuronal apoptosis in the olfactory mucosa of the adult mouse.

Michel D, Moyse E, Trembleau A, Jourdan F, Brun G

J. Cell Sci. 1997 110:1635-43.


In vitro induction of apoptosis or differentiation by dopamine in an immortalized olfactory neuronal cell line.

Coronas V, Feron F, Hen R, Sicard G, Jourdan F, Moyse E

J. Neurochem. 1997 69(5):1870-1881.


Dopaminergic modulation of mitral cell activity in the frog olfactory bulb: a combined radioligand binding-electrophysiological study.

Duchamp-Viret P., Coronas V, Delaleu JC, Moyse E, Duchamp A

Neuroscience 1997 79(1):203-216.


Identification and localization of dopamine receptor subtypes in rat olfactory mucosa and bulb: a combined in situ hybridization and ligand binding radioautographic approach.

Coronas V, Srivastava LK, Liang JJ, Jourdan F, Moyse E

J. Chem. Neuroanat. 1997 12(4):243-257.


Electron microscopic distribution of mu opioid receptors on noradrenergic neurons of the locus coeruleus.

Moyse E, Marcel D, Leonard K, Beaudet A

Eur. J. Neurosci. 1997 9(1):128-139.


An autoradiographic study comparing the interactions of 3 alpha-OH-5-al-pregnan-20-one, pregnenolone sulphate and pentobarbital with 35S-TBPS binding sites and their modulation by GABA in different structures of the rat brain.

Vincens M, Dartois E, Moyse E, Haour F, Fillion G

Naunyn Schmiedeberg’s Arch Pharmacol 1995 351(4):356-362.


Induction of apoptosis in mouse olfactory epithelium by synaptic target ablation.

Michel D, Moyse E, Brun G, Jourdan F

Neuroreport 1994 5:1329-32.


Radioautographic demonstration and localization of glucagon receptors in the duck brain.

Montaron A, Moyse E, Barré H

Brain Res. 1994 663(1):121-130.


VIP binding sites in rat hypothalamus: nuclear distribution and daily variations.

Morin AJ, Moyse E, Denoroy L, Jouvet M

Peptides 1994 15(1):117-123.


Autoradiographic study of neurosteroid binding sites labelled with [35S]-TBPS in brain of different species.

Vincens M, Dartois E, Popelier M, Marquette C, Moyse E, Fillion G, Haour F

Brain Res. Bull. 1993 32(3):251-256.


Short- and long-term effects of nucleus basalis magnocellularis lesions on cortical levels of somatostatin and its receptors in the rat.

Moyse E, Szigethy E, Danger JM, Vaudry H, Wenk GL, Beaudet A, Epelbaum J

Brain Res. 1993 607:154-160.


Possible functions of a new genetic marker in central nervous system: the sulfated glycoprotein-2 (SGP-2).

Michel D, Chabot JG, Moyse E, Danik M, Quirion R (1992)

Synapse 1992 11(2):105-111.


Localization of mu opioid receptors on the membranes of nerve endings and tanycytes in the guinea-pig median eminence by electron microscopic radioautography.

Beauvillain JC, Moyse E, Dutriez I, Mitchell V, Poulain P, Mazzuca M

Neuroscience 1992 49(4):925-936.


Somatotopic organization of tyrosine hydroxylase expression in the rat locaus coeruleus: long term effect of RU24722.

Debure LI, Moyse E, Fevre-Montange M, Hardin H, Belin MF, Rousset C, Pujol JF, Weissmann D

Brain Res. 1992 581(1):19-32.


Light microscopic radioautographic localization of somatostatin binding sites in the brainstem of the rat.

Moyse E, Beaudet A, Bertherat J, Epelbaum J

J. Chem. Neuroanat. 1992 5(1):75-84.


Light microscopic localization of somatostatin binding sites in the locus coeruleus of the rat.

Gagne C, Moyse E, Kocher L, Bour H, Pujol JF

Brain Res. 1990 530(2):196-204.



Regional distribution of somatostatin receptor affinity states in rat brain: effects of divalent cations and GTP.

Moyse E, Slama A, Videau C, DeAngela P, Kordon C, Epelbaum J

Regul Pept. 1989 26(3):225-234.


Combined autoradiographic and immunohistochemical evidence for an association of somatostatin binding sites with growth-hormone-releasing factor-containing nerve cell bodies in the rat arcuate nucleus.

Epelbaum J, Moyse E, Tannenbaum GS, Kordon C, Beaudet A

J. Neuroendocrinol. 1989 1(2):109-115.


Effects of ovariectomy and estradiol replacement on the binding of 125I-neurotensin in rat suprachiasmatic nucleus.

Moyse E, Miller MM, Rostene W, Beaudet A

Neuroendocrinology 1988 48(1):53-60.


Distribution of neurotensin binding sites in the caudal brainstem of the rat: a light microscopic radioautographic study.

Kessler JP, Moyse E, Kitabgi P, Vincent JP, Beaudet A

Neuroscience 1987 23(1):189-198.


Distribution of neurotensin binding sites in rat brain: a light microscopic radioautographic study using monoiodo [125I]Tyr3-neurotensin.

Moyse E, Rostene W, Vial M, Leonard K, Mazella J, Kitabgi P, Vincent JP, Beaudet A

Neuroscience 1987 22(2):525-536.


125I-FK 33-824: a selective probe for radioautographic labelling of mu opioid receptors in the brain.

Moyse E, Pasquini F, Quirion R, Beaudet A

Peptides 1986 7(2):351-355.


Differential effects of passive immunization with somatostatin antiserum on adenohypophysial hormone secretions in starved rats.

Hugues JN, Enjalbert A, Moyse E, Shu C, Voirol MJ, Sebaoun J, Epelbaum J

J. Endocrinol. 1985 109(2):169-174.


Somatostatin receptors in human growth hormone and prolactin-secreting pituitary adenomas.

Moyse E, LeDafniet M, Epelbaum J, Pagesy P, Peillon F, Kordon C, Enjalbert A 

J. Clin. Endocrinol. Metab. 1985 61(1):98-103.


Subcellular distribution of somatostatin-14, somatostatin-28 and somatostatin-28(1-12) in rat brain cortex and comparisons of their respective binding sites in brain and pituitary.

Moyse E, Benoit R, Enjalbert A, Gautron JP, Kordon C, Ling N, Epelbaum

J Regul. Pept. 1984 9(1-2):129-137.


Guanine nucleotide sensitivity of 125I-Iodo-NTyr-somatostatin binding in rat adenohypophysis and cerebral cortex.

Enjalbert A, Rasolonjanahary R, Moyse E, Kordon C, Epelbaum J

Endocrinology 1983 113(2):822-4.


Somatostatin and dementia in Parkinson’s disease.

Epelbaum J, Ruberg M, Moyse E, Javoy-Agid F, Dubois B, Agid Y

Brain Res. 1983 278(1-2):376-9.