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Dernière mise à jour : Mai 2018

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Neuroendocrinologie Moleculaire de la Reproduction

Diabetes Type 2 and Kisspeptin: Central and Peripheral Sex-Specific Actions

Trends in Endocrinology & Metabolism, November 2019, Vol. 30, No. 11

Cell press
Monika Dudek,, Kamil Ziarniak, Marie-Line Cateau, Laurence Dufourny and Joanna Helena Sliwowska
Abstract

Kisspeptin (KP) plays a major role in the regulation of reproduction governed by the hypothalamic–pituitary–gonadal (HPG) axis. However, recent findings suggest that the KP system is present not only centrally (at the level of the hypothalamus), but also in the peripheral organs crucial for the control of metabolism. The KP systemis sexually differentiated in the hypothalamus, and it is of particular interest to study whether sex-specific responses to type 2 diabetes (DM2) exist centrally and peripherally. As collection of data is limited in humans, animal models of DM2 are useful to understand crosstalk between metabolism and reproduction. Sex-specific variations in the KP system reported in animals suggest a need for the development of gender specific therapeutic strategies to treat DM2.