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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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Project funded by the Center Val de Loire Region

Environmental Pollutants (Bisphenols, Ethinylostradiol, Glyphosate) and Female Fertility: Cocktail Effects?

Environmental Pollutants (Bisphenols, Ethinylostradiol, Glyphosate) and Female Fertility: Cocktail Effects?

Coordination: Pascal Vaudin & Virginie Maillard

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Human activity imposes environmental challenge that affects our societies. Synthetic products have contaminated our environment and the consequences for wild and human populations are real. These environmental pollutants have or could exert harmful actions on reproduction via their endocrine disrupting effects. The PERFidE project aims to understand the action of three environmental pollutants, ethinyl estradiol (contraceptive pill), bisphenols and glyphosate on female fertility. The exposure of the oocyte to these pollutants will be measured in the follicular fluid of women in relation to gamete quality and markers of oxidative stress. Analyzes on human cells in culture will make it possible to highlight a possible impact on the cell viability, the metabolism and the functioning of the genome by these three pollutants in single and multiple exposure to test a cocktail effect. A developmental exposure to the cocktail on model animals will be evaluated on reproduction (fertility, neuro-glial networks) and sexual behavior