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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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Research projects

The NHyRVana team belongs to the Reproductive and Behavioral Physiology Unit (PRC) and is part of the Neuroendocrinology, Behavioral Cluster. Our research tackles three main issues:

♦ Identification of the regulatory factors involved in the different stages of the hypothalamic neurogenesis processes: activation of neural stem cells, proliferation, differentiation and cell survival. In this context, we evaluate the effects of endogenous regulators, such as hormones, and exogenous regulators, such as photoperiod, endocrine disruptors, on the establishment and functioning of these new cells within the hypothalamic neuroendocrine networks.

♦ Development of multimodal approaches in neuroimaging. We use state of the art imaging techniques (MRI, Spectroscopy, ScannerX) to study the migration potential of new hypothalamic neurons, their maturation and their integration into existing synaptic circuits. We are developing imaging modalities to characterize the neurogenic potential of the adult mammalian hypothalamus, using the sheep model.
♦ Study of the role of hypothalamic gliogenesis as well as glial cell populations around neural stem cells to explore their participation in the modulation of synaptic circuits.

Our research results could have a substantial impact because they address a fundamental property of brain function: the ability of some neuronal populations to self-renew, a process that is still poorly understood despite its importance for the normal and pathological brain. Our research are implemented in different models of mammals, small ruminants (sheep, goats), and mouse models (mice, rats) according to the scientific question..