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Last update: May 2021

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Integrative gonad biology

Comparative and evolutionary genomics of reproductive functions

Comparative and evolutionary genomics of reproductive functions

The genomes of "higher" vertebrates contain an average of 23,000 to 25,000 genes, and the biological function is known for only a small percentage of them. An alternative to the intensive strategies for creating mutants in vivo is to rely on comparative physiology and genomic data, and more specifically on the systematic study of gene evolution, potentially explanatory of the evolution of major functions between species, and comparisons of large fragments of genomes or whole genomes. It is phylogenomics. The team is interested in the evolution of genes related to reproduction and gametogenesis as well as those related to energy metabolism. In particular, the team studies the moments of birth, death, divergence and convergence of genes related to reproduction, using a phylogenetic approach.

Estienne A, Jarrier P, Staub C, Venturi E, Le Vern Y, DiClemente N, Monniaux D, Monget P. AMH expression in the ovary: a comparative study in bovine and porcine granulosa cells. 2020. Biol Reprod, 103(3) 572-582.

Grandchamp A. & Monget P. The membrane receptors that appeared before their ligand: The different proposed scenarios. 2020. PLoS One 15(5): e0231813.

Grandchamp A, Tahir S, Monget P. Natriuretic peptides appeared after their receptors in vertebrates. BMC Evol Biol. 2019 Nov 26;19(1):215. doi: 10.1186/s12862-019-1517-x.

Grandchamp A, Piégu B, Monget P. Genes Encoding Teleost Fish Ligands and Associated Receptors Remained in Duplicate More Frequently than the Rest of the Genome. Genome Biol Evol. 2019 May 1;11(5):1451-1462. doi: 10.1093/gbe/evz078.

Grandchamp A, Monget P. Synchronous birth is a dominant pattern in receptor-ligand evolution. BMC Genomics. 2018 Aug 14;19(1):611. doi: 10.1186/s12864-018-4977-2.

Moros-Nicolás C, Fouchécourt S, Goudet G, Monget P. Genes Encoding Mammalian Oviductal Proteins Involved in Fertilization are Subjected to Gene Death and Positive Selection. 2018. J Mol Evol. 86:655-667.

Elis S, Desmarchais A, Cardona E, Fouchecourt S, Dalbies-Tran R, Nguyen T, Thermes V, Maillard V, Papillier P, Uzbekova S, Bobe J, Couderc JL, Monget P. Genes Involved in Drosophila melanogaster Ovarian Function Are Highly Conserved Throughout Evolution. Genome Biol Evol. 2018 Oct 1;10(10):2629-2642. doi: 10.1093/gbe/evy158.

Contact : philippe.monget[@]

Inra Val de Loire Image : P. Monget

Arbre phylogénétique des vertébrés montrant la perte d'un gène codant une protéine de la zone pellucide chez les mammifères.
Réalisé par Philippe Monget

(Article de  référence : Goudet G., Mugnier S., Callebaut I., Monget P., 2008. Phylogenetic analysis and identification of pseudogenes reveal a progressive loss of zona pellucida genes during evolution of vertebrates. Biol Reprod 78: 796-806)