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Dernière mise à jour : Mai 2018

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Our Charter

The purpose of this charter is to set out the conditions of use of the platform and must be read and understood by all users before using the services it offers.

Charter for the use of the PIXANIM platform
The purpose of this charter is to set out the conditions of use of the platform and must be read and understood by all users before using the services it offers.
It is defined beforehand that any person (academic or industrial collaborator) using the platform's services is considered as a user.

A- Missions of the platform
The PIXANIM platform (Phenotyping by in/eX vivo Imaging from the ANImal to the Molecule), IBiSA-labelled and ISO 9001 v2015 certified, is located at the INRAE Val de Loire Centre (Nouzilly), and is hosted by the UMR PRC (Mixed Research Unit for Reproductive and Behavioural Physiology; UMR INRAE 85, CNRS 7247, University of Tours, IFCE).
PIXANIM supports both agronomic research to ensure the improvement of the multi-performance of livestock farming (for more efficient production systems, respectful of the well-being and health of animals and the environment) and medical research for the development of new therapies and the use of animal models for pre-clinical research.
The platform provides experimental resources and develops complementary and analytical methods dedicated to multi-scale animal phenotyping. Thanks to in vivo and/or ex vivo investigation tools, PIXANIM provides in-depth knowledge of the anatomy, structures, functions and metabolism of the different biological systems making up the animal. PIXANIM allows the study of the different biological systems of the animal from the scale of the whole individual to the cellular and molecular levels.
PIXANIM thus allows both phenotyping and characterisation of the molecular mechanisms explaining phenotypes, and this for a wide range of large animal models, particularly livestock and wildlife.
PIXANIM aims to:
- to provide the scientific community with a complementary set of expertise in peri-surgery, imaging and molecular analysis adapted to studies of physiology and integrative biology of animals;
- to develop new animal phenotyping methods;
- research molecular markers for the development of diagnostic tests in humans and animals.

B- Commitments of the PIXANIM platform
Design and formalisation of the offer.
Any analysis request submitted by a user is examined by the person(s) responsible for the activities concerned (Perichirurgery, Imaging, Molecular Analysis) on a scientific, financial and ethical level. PIXANIM is obliged to respond to any request, and in case of non feasibility, the reasons will be explained.
A welcome report will be written by PIXANIM and will detail :
- the scientific context of the experimentation,
- the project objectives according to a defined experimental design,  
- the analytical strategies proposed and selected,
- regulatory implications (animal ethics),
- planning on the basis of known deadlines (contracts, doctorates, etc.), the availability of staff and their infrastructure and equipment,
- the level of participation of the PIXANIM platform (collaboration or service) and of the interlocutors (co-authors in the publications).
In addition to this welcome report, the PIXANIM platform will provide the user with a financial evaluation in the form of an estimate or a contract including the amount of the offers, based on the rates in force.
Realization of the analyses and data storage
The platform is committed to :
- Provide recommendations for the preparation of samples/animals and information on the use of its infrastructure and equipment.
- Mobilise all the appropriate means for carrying out the experiments and exploiting the results (premises, equipment, IT).
- Inform users in a detailed manner about the problems linked to an analysis.
- To ensure the smooth running of the experimental work but reserves the right to interrupt or suspend access to the various equipment and their operation for imperative technical reasons.
- Ensure the confidentiality of projects and results obtained, unless specifically agreed with users.
- Report on the experiments carried out and give advice on the follow-up to be given to the experiments carried out.
- Accompany users in the valorisation of the work
- Encourage the dissemination of data in dedicated repositories for sharing with the scientific community in line with INRAE's data sharing policy.
 The platform undertakes to keep the remaining samples for one year after analysis, and to back up and archive the data for a maximum of 8 years (locally and at the Data Center).
C- Commitments of the users of the PIXANIM platform
Request for services :

Users agree to :
- To contact the platform management and/or the person in charge of the activities concerned (peri-surgery, imaging, molecular analyses) and to inform them about the scientific context, the objectives of the experiment and to provide all the necessary information for the realisation (additional form to be filled in when necessary).
- Consult with the person(s) in charge of the activities concerned to establish the role of the platform in the implementation of the project (collaboration, services) and the interlocutors (co-authors in the publications).
- Define together the schedule for the experiments
- Provide samples prepared according to the platform's recommendations
- To give access to databases or any other information allowing the realization of the experiments or their exploitation.
Contractualisation :
The users commit themselves, even in a collaborative framework, to participate financially in the costs of the experiments and infrastructures according to the current tariff. The financial aspects are governed either by a research or service provision contract or, for an amount of < 15 keuros, by an invoicing procedure following the sending of a purchase order and a signed estimate. Experiments can only begin after the signature of a quotation or contract referring to this charter. Consequently, users undertake to respect it on each of its points.
Animal models and ethics :
In the case of projects involving animals, users must provide all the information on the desired animal model: species, breed, physiological stage, age, weight, as well as, if applicable, the experimental intervention(s) planned and the care required. They must also provide all the information on the products they wish to use to carry out the analyses.
Any project requiring analysis by in vivo imaging must be subject to an application for authorisation in accordance with the procedure defined in the regulatory texts (directive 2010/63/EU). This procedure involves the user submitting a referral document to the Val de Loire Animal Experimentation Ethics Committee (CEEA VdL) before the start of the imaging analyses and its validation by the Ministry of Research and Industry.
Any act (anaesthesia, surgery, care, etc.) carried out on the animal outside of imaging analyses is carried out under the responsibility of a user with level I authorisation to carry out experiments. The user will have to provide the documents justifying a training course in level I experimentation on livestock, his competency booklet and his diploma.
Access to premises and protection of personnel :
The carrying out of analyses may involve welcoming external people to the PIXANIM platform premises: users and their possible guests (medical, technical, industrial partners...). Prior to any experimentation on the platform's premises, users from outside INRAE must ask their organisation to sign a prevention plan with INRAE. A model prevention plan can be provided by INRAE if necessary. Experiments cannot begin until the plan has been drawn up.  Users also undertake to provide a list of the names of the external persons (name + employer) who will come to the INRAE premises before the date of the analyses.
Radioprotection :
For the use of the image intensifier, users must refer to a specific procedure (Annex 1) in relation to the radiation protection of personnel handling X-ray/radiography equipment with X-ray emitters in the Industry Research sector. Access to and use of the X-ray equipment is only allowed when Annex I is completed and provided to the platform. The experimenter shall comply with the instructions of the Platform's Competent Person for Radiation Protection. The experimenter must wear the Personal Protective Equipment (PPE: apron, goggles, leaded throat cover, screen) provided by PIXANIM as well as an operational dosimetry badge. If it is necessary to declare significant radiation protection events, the user undertakes to report this without delay to the PCRs of the two parties who will take charge of processing the file for final declaration to the ASN by the licence holder.
Communication of results :
The valuation of the results must follow the normal rules of signature and acknowledgement. The applicant undertakes to have the platform staff who conducted the experiments co-sign if the results produced by the platform are essential to the article or communication (posters, presentations). In this case, the portions of the article (material and methods, results, figures) relating to the platform's activities will be submitted to the PIXANIM staff concerned for proofreading or writing if necessary. The platform's contact details must appear clearly on all other documents (internship reports, theses, press articles, etc.).
If the results produced by the platform are not essential to the article or communication, the applicant undertakes to thank the platform for the equipment made available and/or the people of the platform for their participation in the analyses.
The platform will be informed of the fate of the results: articles, posters, communications, theses, dissertations. A copy of all these forms of "publications" must obligatorily be provided to PIXANIM.

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C- Engagements des utilisateurs de la plate-forme PIXANIM

 

Demande de prestations

Les utilisateurs s’engagent à :

-        Prendre contact avec la direction de la plate-forme et/ou le responsable des activités concernées (péri-chirurgie, imagerie, analyses moléculaires) et à les informer sur le contexte scientifique, les objectifs de l’expérience et à fournir toutes les informations nécessaires pour la réalisation (formulaire supplémentaire à remplir quand nécessaire).

-        Se concerter avec le ou les responsables des activités concernées pour établir le rôle de la plate-forme dans la réalisation du projet (collaboration, prestation) et des interlocuteurs (co-auteurs dans les publications.

-        Définir ensemble le planning de déroulement des expériences

-        Fournir les échantillons préparés selon les recommandations de la plate-forme

-        Donner accès aux bases de données ou toutes autres informations permettant la réalisation des expériences ou leur exploitation.

 

Contractualisation

 

Les utilisateurs s’engagent, même dans un cadre collaboratif, à participer financièrement aux coûts des expériences et des infrastructures en fonction de la tarification en vigueur. Les aspects financiers sont encadrés soit par un contrat de recherche, de prestations de recherche ou de prestation de service soit, pour un montant < 15 keuros, par une procédure de facturation faisant suite à l’envoi d’un bon de commande et d’un devis signé. Les expériences ne pourront débuter qu’après la signature d’un devis ou contrat faisant référence à cette charte. Par conséquent, les utilisateurs s’engagent à la respecter sur chacun de ses points.

 

Modèles animaux et éthique.

 

Dans le cas de projets impliquant des animaux, les utilisateurs doivent fournir toutes les informations sur le modèle animal souhaité : espèce, race, stade physiologique, âge, poids, ainsi que, le cas échéant, la ou les interventions expérimentales programmées ainsi que les soins requis. Ils doivent également fournir toutes les informations sur les produits qu’ils souhaitent utiliser pour pratiquer les analyses.

 

Tout projet nécessitant une analyse par imagerie in vivo devra faire l’objet d’une demande d’autorisation selon la procédure définie dans les textes réglementaires (directive 2010/63/UE). Cette procédure implique, avant le début des analyses d’imagerie, la soumission par l’utilisateur d’un document de saisine au Comité d'Éthique en Expérimentation Animale Val de Loire (CEEA VdL) et sa validation par le Ministère de la Recherche et de l’Industrie.

Tout acte (anesthésie, intervention chirurgicale, soins…) réalisé sur l’animal en dehors des analyses d’imagerie est exécuté sous la responsabilité d’un utilisateur détenant l’autorisation d’expérimenter de niveau I. L’utilisateur devra fournir les documents justifiant d’une formation à l’expérimentation de niveau I sur animaux de rente, son livret de compétence et son diplôme.

 

Accès aux locaux et protection des personnels

 

La réalisation des analyses peut impliquer l’accueil de personnes extérieures dans les locaux de la plate-forme PIXANIM : les utilisateurs et leurs éventuels invités (partenaires médicaux, techniques, industriels…). Avant toute expérimentation dans les locaux de la plate-forme, les utilisateurs extérieurs à INRAE doivent demander à leur organisme de signer avec INRAE un plan de prévention. Un modèle de plan de prévention pourra être fourni par INRAE si besoin. Les expérimentations ne pourront pas débuter tant que ce dernier ne sera pas établi.  Les utilisateurs s’engagent par ailleurs, avant la date de réalisation des analyses, à fournir la liste nominative des personnes extérieures (nom + employeur) qui viendront dans les locaux de INRAE.

 

Radioprotection

 

Pour l’utilisation de l’amplificateur de brillance, les utilisateurs doivent se reporter à une procédure spécifique (annexe 1) en lien avec la radioprotection des personnels manipulant des appareils de radioscopie/radiographie comportant des émetteurs de rayons X dans le secteur Industrie Recherche. L’accès et l’utilisation de l’appareils de radiographie ne sont autorisés que lorsque l’annexe I est remplie et fournie à la plateforme. L’expérimentateur devra se conformer aux directives de la Personne Compétente en Radioprotection de la plate-forme. L’expérimentateur devra porter les Équipements de Protection Individuels (EPI : tablier, lunette, cache gorge plombé, paravent) mis à sa disposition par PIXANIM ainsi qu’un badge de dosimétrie opérationnelle. En cas de nécessité de déclaration d’évènements significatifs de radioprotection, l’utilisateur s’engage à le signaler sans délai aux PCR des deux parties qui prendront en charge l’instruction du dossier pour déclaration finale à l’ASN par le titulaire de l’autorisation.

 

Communication des résultats

 

La valorisation des résultats doit suivre les règles normales de signature et de remerciements. Le demandeur s’engage à faire co-signer les personnels de la plate-forme ayant mené les expériences si les résultats produits par la plate-forme sont essentiels à l'article ou à la communication (posters, présentations). Dans ce cas, les portions d'article (matériel et méthodes, résultats, figures) se rapportant aux activités de la plate-forme seront soumises au personnel de PIXANIM concerné pour relecture ou rédaction si nécessaire. Les coordonnées de la plate-forme devront apparaître clairement sur tout autre document (mémoires de stages, thèses, articles de presse…).

Si les résultats produits par la plate-forme ne sont pas essentiels à l'article ou à la communication, le demandeur s’engage à remercier la plate-forme pour l'équipement mis à disposition et/ou les personnes de la plate-forme pour leur participation aux analyses.

La plate-forme sera informée du devenir des résultats : articles, posters, communications, thèses, mémoires de stages. Un exemplaire de toutes ces formes de « publications » doit obligatoirement être fourni à PIXANIM.