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Last update: May 2021

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Infectious Diseases and Public Health

French National Institute for Agricultural Research - University of Tours (France)

Signalling, carrier state and bacterial virulence

Cell surface rearrangements induced by Salmonella invasion mechanisms
© Inra, A Wiedemann - University of Tours, PY Sizaret
Team leader: Philippe Velge

Depending of the hosts and the serotypes, Salmonella induce a wide spectrum of diseases among which gastro-enteritis, typhoid fever and asymptomatic infections.

Within the host, Salmonella is able to infect a large array of cells, leading to the paradigm that cell invasion is a key step in Salmonella pathogenesis. The role of this step in Salmonella pathogenesis has been neglected due to the belief that  Salmonella  has only one entry pathway: the T3SS-1. However, at least two other entry factors were identified recently.

We focus our research on the :

  • mechanisms of Salmonella carrier state in chicken by comparison to Salmonella virulence in susceptible mice;
  • impact of intestinal microbiota on transmission and host infection;
  • role of the different cell invasion pathways in the pathogenesis of Salmonella.

We use complementary approaches :

  • characterization and regulation of bacterial factors involved in Salmonella-cell interactions in relation to virulence and asymptomatic carrier state ;
  • identification and characterization of the T3SS-1 independent cell entry mechanisms mediated by Salmonella and the behaviours following these entries ;
  •  in vivo mechanisms involved in resistance to carrier state and transmission between chicks.

Pubmed since 2012


Scientific Staff

and Assistant-Engineers

PhD students

Grépinet Olivier
Holbert Sébastien
Kempf Florent
Lalmanach Anne-Christine
Schouler Catherine
Velge Philippe
Virlogeux-Payant Isabelle

Barilleau Emilie
Trotereau Jérôme

Agapé Lorna
Nicolas Marianne