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24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

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Infectious Diseases and Public Health

French National Institute for Agricultural Research - University of Tours (France)

Bacteria and maternal/fœtal risk

Streptococcus agalactiae culture on Granada agar and blood agar
© University of Tours, L. Mereghetti
Team leader: Laurent Mereghetti

Our team’s model is Streptococcus agalactiae, a commensal bacterium of the human intestinal and genital tracts, which cause invasive infections in neonates and immunocompromised adults.

Despite the implementation of prophylactic measures, S. agalactiae remains the major cause of neonatal infections with an overall mortality rate of approximately 10%.
Our main research activities focus on:

  • investigating the genetic diversity of the CRISPR/cas system and the bacteriophage content of S. agalactiae strains, and the potential link to virulence;
  • understanding the regulatory mechanisms governed by carbohydrate metabolism and trace metal acquisition, to define the networks regulating the bacterium adaptation and colonization in various ecological niches;
  • characterizing the bacterium regulatory small RNAs (sRNAs) and understanding their role in physiology regulation, host adaptation and virulence factor expression.

Pubmed since 2012


Scientific staff


PhD students

Camiade Emilie
Gilot Philippe
Hiron Aurélia
Lanotte Philippe
Lartigue Marie-Frédérique
Mereghetti Laurent
Morello Eric
Quentin Roland
Rosenau Agnès
Valentin-Domelier Anne-Sophie
van der Mee-Marquet Nathalie

Niquet Daniel
Rong Vanessa

Melet Morgane
Moussounda Mesmin
Roux Anne-Emmanuelle