Team leaders: Anne Collin (PhD) and Sophie Tesseraud (PhD)

General objectives:

The work of the team aims to improve knowledge of the mechanisms regulating growth and metabolism to control the development of poultry, their body composition, and meat quality and improve their ability to adapt to farming conditions (including climate variations). In fine, these studies will contribute to improve health and welfare while ensuring the quality of poultry production. The activity of the team is dedicated to the study of energy and protein metabolism and muscle biology, through targeted molecular and high-throughput studies conducted in vivo and in vitro on the regulation of gene expression, intracellular signalling pathways and metabolic or hormonal parameters whose variations regulate the investigated phenotypes of interest. Epigenetic mechanisms associated with phenotypic changes induced by early stimulations are currently explored in the Japanese quail within multigenerational studies.

Research Topics:

	Physiological and epigenetic mechanisms controlling early adaptation : Early environmental changes can affect physiology and chick quality, and can change adaptive capacities and long-term health. Our goal is to understand the underlying molecular mechanisms on original models of embryonic acclimation (to heat and cold) and perinatal rearing conditions.
	Long-term modulation of metabolism and growth by nutrition :  Our work aims to identify the nutrients that induce early metabolic programming in birds and to understand the mechanisms capable of orienting protein and energy metabolism during breeding.
	Molecular and cellular mechanisms controlling meat quality :  The aim is to characterize the key players involved in the regulation of energy stores and muscle development in order to optimize the processing ability and sensorial quality of meat while preserving animal health and welfare.
	Design and evaluation of innovations related to meat production practices :  In conjunction with the generic knowledge gained, we contribute to the design and evaluation of robust meat production systems, respectful of animals and the environment, in a sustainability perspective.

Ongoing projects:

- H2020 European project PPILOW, 2019-2024: Poultry and PIg Low-input and Organic production systems’ Welfare
- AGENAVI BMW, 2018-2019 : Breast Muscle Wave : Evaluation of the contribution of medical imaging for the in vivo prediction of the chicken breast defect.
- CASDAR/RT CHICK’TIP, 2018-2021: Early monitoring the quality of chicken for more sustainable poultry production.
- CASDAR/RT MEXAVI, 2017-2020: Development of a proven methodology to evaluate the ability of plant extracts to strengthen the natural defenses of poultry, from the selection of extracts to the measurement of biological effectiveness.
- ANR JCJC QuailHeatE, 2016-2019: Epigenetic mechanisms of embryonic heat conditioning in quail.
- INRA GISA ROBUSTCHICK, 2016-2017: Variations in incubation temperature as an innovative technique to improve the robustness, health and welfare of thermally-challenged meat-type chickens.
- REGIONS Bretagne/Pays de Loire TECNOVIA, 2015-2017: Characterization of the technological defects of chicken and pork meat; design of improvement strategies through genetics and nutrition.
- CASDAR/RFI OPTIVIANDE, 2014-2017: Optimization of chicken processing meat quality through the development of molecular tests used in breeding and selection.
- INRA GISA WHELP, 2014-2017: Welfare-Health in Early Life Program.

Major publications:

Beauclercq S., Lefèvre A., Montigny F., Collin A., Tesseraud S., Leterrier C., Emond P., Guilloteau L. (2019). A multiplatform metabolomic approach to characterize fecal signatures of negative postnatal events in chicks: a pilot study. J. Anim. Sci. Biotechnol. doi: 10.1186/s40104-019-0335-8

Belloir P., Lessire M., Lambert W., Corrent E., Berri C., Tesseraud S. (2019). Changes in body composition and meat quality in response to dietary amino acid provision in finishing broilers. Animal. 2018 Oct 5:1-9. doi: 10.1017/S1751731118002306.

Chartrin P., Bordeau T., Godet E., Meteau K., Gicquel J.C., Drosnet E., Brière S., Bourin M., Baéza E. (2019). Is meat of breeder turkeys so different from that of standard turkeys? Foods, 8 (1), 8, 12 p.

Guilloteau LA, Collin A, Koch A, Leterrier C (2019). Spontaneous Intake and Long-Term Effects of Essential Oils After a Negative Postnatal Experience in Chicks. Front. Vet. Sci., 15 March 2019. doi: 10.3389/fvets.2019.00072.

Vitorino Carvalho A., Couroussé N., Crochet S., Coustham V. (2019). Identification of Reference Genes for Quantitative Gene Expression Studies in Three Tissues of Japanese Quail. Genes, Mar 4;10(3). pii: E197. doi: 10.3390/genes10030197.

Pampouille E, Berri C, Boitard S, Hennequet-Antier C, Beauclercq SA, Godet E, Praud C, Jégo Y, Le Bihan-Duval E (2018) Mapping QTL for white striping in relation to breast muscle yield and meat quality traits in broiler chickens. BMC Genomics. 19(1):202. doi: 10.1186/s12864-018-4598-9.

Coudert E, Praud C, Dupont J, Crochet S, Cailleau-Audouin E, Bordeau T, Godet E, Collin A, Berri C, Tesseraud S, Métayer-Coustard S. (2018). Expression of glucose transporters SLC2A1, SLC2A8, and SLC2A12 in different chicken muscles during ontogenesis. J Anim Sci. 96(2):498-509. doi: 10.1093/jas/skx084.

Travel A., Cariou R., Royer E., Méda B., Baéza E., Ratel J., Amand G., Balaine L., Cotton J., Venisseau A., Dominguez-Romero E., Marchand P., Le Bourhis C., Dervilly-Pinel G., Marcon M., Mercier F., Souchet C., Thomas R., Le Bizec B., Engel E., Huneau-Salaün A., Le Bouquin S., Jondreville C. (2018). Retardateurs de flammes bromés dans produits avicoles et porcins : état des lieux, modalités de transfert et facteurs de risques. Innovations Agronomiques, 63, 115-137. 23 pages.

Baéza E., Chartrin P., Bordeau T., Lessire M., Thoby J.M., Gigaud V., Blanchet M., Alinier A., Leterrier C. (2017). Omega-3 polyunsaturated fatty acids n-3 provided during embryonic development improve the growth performance and welfare of Muscovy ducks (Cairina moschata). Poultry Science, 96 (9), 3176-3187.

Beauclercq S, Hennequet-Antier C, Praud C, Godet E, Collin A, Tesseraud S, Métayer-Coustard S, Bourin M, Moroldo M, Martins F, Lagarrigue S, Bihan-Duval E, Berri C. (2017). Muscle transcriptome analysis reveals molecular pathways and biomarkers involved in extreme ultimate pH and meat defect occurrence in chicken. Scientific Report 7(1):6447.

Belloir P, Méda B, Lambert W, Corrent E, Juin H, Lessire M, Tesseraud S. (2017). Reducing the CP content in broiler feeds: impact on animal performance, meat quality and nitrogen utilization. Animal. 2017 May 2:1-9.

David, S.-A., Piégu, B., Hennequet-Antier, C., Pannetier, M., Aguirre-Lavin, T., Crochet, S., Bordeau, T., Couroussé, N., Brionne, A., Bigot, Y., Collin, A., Coustham, V. (2017). An assessment of fixed and native chromatin preparation methods to study histone post-translational modifications at a whole genome scale in skeletal muscle tissue. Biol Proced Online. 29;19:10. doi: 10.1186/s12575-017-0059-0. eCollection 2017.

Nyuiadzi D, Travel A, Méda B, Berri C, Guilloteau LA, Coustham V, Wang Y, Tona JK, Collin A. (2017). Effect of low incubation temperature and low ambient temperature until 21 days of age on performance and body temperature in fast-growing chickens. Poult Sci. 96(12):4261-4269. doi: 10.3382/ps/pex264.

Praud C, Al Ahmadieh S, Voldoire E, Le Vern Y, Godet E, Couroussé N, Graulet B, Le Bihan Duval E, Berri C, Duclos MJ. (2017). Beta-carotene preferentially regulates chicken myoblast proliferation withdrawal and differentiation commitment via BCO1 activity and retinoic acid production. Exp Cell Res. pii: S0014-4827(17): 30340-3.

Baéza E. (2016). Nutritional requirements and feed management of meat type ducks. World’s Poultry Science Journal, 72, 5-19.

Beauclercq, S., L. Nadal-Desbarats, C. Hennequet Antier, A. Collin, S. Tesseraud, M. Bourin, E. Le Bihan-Duval, C. Berri (2016). Serum and Muscle Metabolomics for the Prediction of Ultimate pH, a Key Factor for Chicken-Meat Quality. Journal of Proteome Research 15(4): 1168–1178.

Loyau, T., C. Hennequet-Antier, V. Coustham, C. Berri, M. Leduc, S. Crochet, M. Sannier, M. J. Duclos, S. Mignon-Grasteau, S. Tesseraud, A. Brionne, S. Metayer-Coustard, M. Moroldo, J. Lecardonnel, P. Martin, S. Lagarrigue, S. Yahav and A. Collin (2016). Thermal manipulation of the chicken embryo triggers differential gene expression in response to a later heat challenge. BMC Genomics 17(1): 15 p.

Alnahhas, N., E. Le Bihan-Duval, E. Baeza, M. Chabault, P. Chartrin, T. Bordeau, E. Cailleau-Audouin, K. Meteau, C. Berri (2015). Impact of divergent selection for ultimate pH of pectoralis major muscle on biochemical, histological, and sensorial attributes of broiler meat. Journal of Animal Science 93(9): 4524 - 4531.

Baeza, E., M. Jégou, F. Gondret, J. Lalande-Martin, I. Tea, E. Le Bihan-Duval, C. Berri, A. Collin, S. Métayer Coustard, I. Louveau, S. Lagarrigue, M. J. Duclos (2015). Pertinent plasma indicators of the ability of chickens to synthesize and store lipids. Journal of Animal Science 93(1): 107-116.

Coudert, E., G. Pascal, J. Dupont, J. Simon, E. Cailleau-Audouin, S. Crochet, M. J. Duclos, S. Tesseraud, S. Métayer Coustard (2015). Phylogenesis and biological characterization of a new glucose transporter in the chicken ([i]Gallus gallus[/i]), GLUT12. Plos One 10(10): 1-18.

Guardia, S., M. Lessire, A. Corniaux, S. Métayer Coustard, F. Mercerand, S. Tesseraud, I. Bouvarel and C. Berri (2014). Short-term nutritional strategies before slaughter are effective in modulating the final pH and color of broiler breast meat. Poultry Science 93(7): 1764–1773.

Loyau, T., S. Métayer Coustard, C. Berri, S. Crochet, E. Cailleau-Audouin, M. Sannier, P. Chartrin, C. Praud, C. Hennequet Antier, N. Rideau, N. Couroussé, S. Mignon-Grasteau, N. Everaert, M. J. Duclos, S. Yahav, S. Tesseraud and A. Collin (2014). Thermal manipulation during embryogenesis has long-term effects on muscle and liver metabolism in fast-growing chickens. Plos One 9(9): 13 p.

Tesseraud, S., P. Chartrin, S. Métayer Coustard, D. Hermier, N. Simon, C. Peyronnet, M. Lessire and E. Baeza (2014). Modulation of the insulin anabolic signalling cascade in growing chickens by n-3 PUFA. British Journal of Nutrition 111(5): 761 - 772.

Everaert, N., S. Métayer Coustard, H. Willemsen, H. Han, Z. Song, Z. Ansari, E. Decuypere, J. Buyse and S. Tesseraud (2013). The effect of albumen removal before incubation (embryonic protein under-nutrition) on the post-hatch performance, regulators of protein translation activation and proteolysis in neonatal broilers. British Journal of Nutrition 110: 265-274.

Baéza, E., C. Arnould, M. Jlali, P. Chartrin, V. Gigaud, F. Mercerand, C. Durand, K. Meteau, E. Le Bihan-Duval and C. Berri (2012). Influence of increasing slaughter age of chickens on meat quality, welfare, and technical and economic results. Journal of Animal Science 90(6): 2003-2013.

Jlali, M., B. Graulet, B. Chauveau-Duriot, M. Chabault, E. Godet, S. Leroux, C. Praud, E. Le Bihan-Duval, M. J. Duclos and C. Berri (2012). A mutation in the promoter of the chicken β,β-carotene 15,15′-monooxygenase 1 gene alters xanthophyll metabolism through a selective effect on its mRNA abundance in the breast muscle. Journal of Animal Science 90(12): 4280-4288.